Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 11;24(1):436.
doi: 10.1186/s12888-024-05898-7.

Investigating CHRNA5, CHRNA3, and CHRNB4 variants in the genetic landscape of substance use disorder in Jordan

Laith Al-Eitan  1 , Mohammad Shatnawi  2 , Mansour Alghamdi  3   4
Affiliations

Investigating CHRNA5, CHRNA3, and CHRNB4 variants in the genetic landscape of substance use disorder in Jordan

Laith Al-Eitan et al. BMC Psychiatry. .

Abstract

Background: Substance use disorder (SUD) is a complex illness that can be attributed to the interaction between environmental and genetic factors. The nicotinic receptor gene cluster on chromosome 15 has a plausible association with SUD, particularly with nicotine dependence.

Methods: This study investigated 15 SNPs within the CHRNA5, CHRNA3, and CHRNB4 genes. Sequencing was used for genotyping 495 Jordanian males with SUD and 497 controls matched for age, gender, and descent.

Results: Our findings revealed that none of the tested alleles or genotypes were correlated with SUD. However, our analysis suggests that the route of substance use was linked to rs1051730 (P value = 0.04), rs8040868 (P value = 0.01) of CHRNA3, and rs16969968 (P value = 0.03) of CHRNA5. Additionally, a correlation was identified between rs3813567 of the CHRNB4 gene and the age at substance use onset (P value = 0.04).

Conclusions: Variants in CHRNA5, CHRNA3, and CHRNB4 may interact with SUD features that can influence the development and progression of the disorder among Jordanians.

Keywords: CHRNA3; CHRNA5; CHRNB4; Nicotinic receptor genes; Substance Use Disorder.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

    1. -Tran BX, Moir M, Latkin CA, et al. Global research mapping of substance use disorder and treatment 1971–2017: implications for priority setting. Subst Abuse Treat Prev Policy. 2019;14:21. doi: 10.1186/s13011-019-0204-7. - DOI - PMC - PubMed
    1. McLellan AT. Substance misuse and substance use disorders: why do they Matter in Healthcare? Transactions of the American Clinical and Climatological Association 128(2017):112–30. - PMC - PubMed
    1. Uchtenhagen A. Substance use problems in developing countries. Bull World Health Organ. 2004:639–718. - PMC - PubMed
    1. Sarvet AL, and Deborah Hasin. The natural history of substance use disorders. Curr Opin Psychiatry 29,4(2016):250–7. 10.1097/YCO.0000000000000257. - PMC - PubMed
    1. -Al-Eitan LN, Jaradat SA, Hulse GK, Tay GK. Custom genotyping for substance addiction susceptibility genes in jordanians of arab descent. BMC Rese Notes. 2012;5(1):497. doi: 10.1186/1756-0500-5-497. - DOI - PMC - PubMed

Publication types

Substances