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Published Erratum
. 2024 Jun 11;12(1):92.
doi: 10.1186/s40478-024-01789-w.

Correction: SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex

Jennifer L Brown  1   2   3 , Damyan W Hart  2   3 , Gabriel E Boyle  2   3   4 , Taylor G Brown  2   5   3 , Michael LaCroix  2   3   6 , Andrés M Baraibar  2   7 , Ross Pelzel  1   2   3 , Minwoo Kim  2   3 , Mathew A Sherman  2   3 , Samuel Boes  2   3 , Michelle Sung  2   3   8 , Tracy Cole  9   10 , Michael K Lee  2   3 , Alfonso Araque  1   2 , Sylvain E Lesné  11   12   13
Affiliations
Published Erratum

Correction: SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex

Jennifer L Brown et al. Acta Neuropathol Commun. .
No abstract available

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Figures

Fig. 1
Fig. 1
ASO1 disperses throughout the brain and lowers SNCA gene expression. A Infra-red imaging documenting the widespread distribution of ASOs 3 weeks after injection using anti- ASO (pink) and anti-αSyn (4D6, green) antibodies. B Reduction in SNCA mRNA at 2 and 3 weeks post-injection as determined by RT-qPCR. C Confocal imaging illustrating the presence of ASO1 (pink) and a corresponding decrease in αSyn (green) in mouse hippocampi. D Quantification of hippocampal 4D6 immunoreactivity in ASO1 or PBS treated mice. E Infra-red imaging detectedαSyn (green) and ASO (pink) in coronal brain sections from PBS and ASO treated mice. The relative αSyn signal was lower in ASO-injected animals than in PBS-injected animals (pseudocolor). F, G Measurements of SNCA mRNA abundance by RT-qPCR (F) and αSyn protein amounts by immunofluorescence (G) in transgenic (APP) and non-transgenic (NTG) animals treated with PBS or ASO. Histogram bars represent mean ± SEM. ★P < 0.05 compared to NTG + PBS, ☆P < 0.05 compared to APP + PBS
Fig. 1
Fig. 1
ASO1 disperses throughout the brain and lowers SNCA gene expression. A Infra-red imaging documenting the widespread distribution of ASOs 3 weeks after injection using anti- ASO (pink) and anti-αSyn (4D6, green) antibodies. B Reduction in SNCA mRNA at 2 and 3 weeks post-injection as determined by RT-qPCR. C Confocal imaging illustrating the presence of ASO1 (pink) and a corresponding decrease in αSyn (green) in mouse hippocampi. D Quantification of hippocampal 4D6 immunoreactivity in ASO1 or PBS treated mice. E Infra-red imaging detectedαSyn (green) and ASO (pink) in coronal brain sections from PBS and ASO treated mice. The relative αSyn signal was lower in ASO-injected animals than in PBS-injected animals (pseudocolor). F, G Measurements of SNCA mRNA abundance by RT-qPCR (F) and αSyn protein amounts by immunofluorescence (G) in transgenic (APP) and non-transgenic (NTG) animals treated with PBS or ASO. Histogram bars represent mean ± SEM. ★P < 0.05 compared to NTG + PBS, ☆P < 0.05 compared to APP + PBS
See this image and copyright information in PMC

Erratum for

References

    1. Brown JL, Hart DW, Boyle GE, et al. NCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex. Acta Neuropathol Commun. 2022;10:180. doi: 10.1186/s40478-022-01480-y. - DOI - PMC - PubMed

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