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. 2024 May 7:5:1338597.
doi: 10.3389/fcdhc.2024.1338597. eCollection 2024.

Is gestational diabetes mellitus in lean women a distinct entity warranting a modified management approach?

Pradnyashree Wadivkar  1 , Meredith Hawkins  1
Affiliations

Is gestational diabetes mellitus in lean women a distinct entity warranting a modified management approach?

Pradnyashree Wadivkar et al. Front Clin Diabetes Healthc. .

Abstract

During pregnancy, insulin resistance and impaired insulin secretion may lead to the development of Gestational Diabetes Mellitus (GDM). Although a higher Body Mass Index (BMI) is often cited as a risk factor for the development of GDM, lean pregnant women are also at risk of developing GDM based on evidence from several studies. It is proposed that insulin deficiency (more than insulin resistance) leads to the development of GDM in women with low BMI (BMI <18.5 kg/m2). Neonates of these women are more at risk of preterm birth and small-for-gestational-age. Given this unique pathophysiology and phenotype, this entity needs a modified management approach. This article aims to raise awareness of GDM in lean women to encourage more research on this topic and create a modified management approach.

Keywords: BMI; GDM; gestational diabetes; insulin deficiency; insulin secretion; lean women.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Prevalence of low BMI diabetes in low-middle-income countries. *Current population of the 29 LMICs mentioned in the reference article.
See this image and copyright information in PMC

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