Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May 7:5:1338597.
doi: 10.3389/fcdhc.2024.1338597. eCollection 2024.

Is gestational diabetes mellitus in lean women a distinct entity warranting a modified management approach?

Pradnyashree Wadivkar  1 , Meredith Hawkins  1
Affiliations

Is gestational diabetes mellitus in lean women a distinct entity warranting a modified management approach?

Pradnyashree Wadivkar et al. Front Clin Diabetes Healthc. .

Abstract

During pregnancy, insulin resistance and impaired insulin secretion may lead to the development of Gestational Diabetes Mellitus (GDM). Although a higher Body Mass Index (BMI) is often cited as a risk factor for the development of GDM, lean pregnant women are also at risk of developing GDM based on evidence from several studies. It is proposed that insulin deficiency (more than insulin resistance) leads to the development of GDM in women with low BMI (BMI <18.5 kg/m2). Neonates of these women are more at risk of preterm birth and small-for-gestational-age. Given this unique pathophysiology and phenotype, this entity needs a modified management approach. This article aims to raise awareness of GDM in lean women to encourage more research on this topic and create a modified management approach.

Keywords: BMI; GDM; gestational diabetes; insulin deficiency; insulin secretion; lean women.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Prevalence of low BMI diabetes in low-middle-income countries. *Current population of the 29 LMICs mentioned in the reference article.
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention . Centers for disease control and prevention, in: Gestational Diabetes (2022). Available online at: https://www.cdc.gov/diabetes/basics/gestational.html (Accessed 2023 Oct 9).
    1. Dinh Le T, Minh Bui T, Hien Vu T, Phi Thi Nguyen N, Thanh Thi Tran H, Nguyen ST, et al. . Insulin resistance in gestational diabetes mellitus and its association with anthropometric fetal indices. Clin. Med. Insights Endocrinol. Diabetes. (2022) 15. doi: 10.1177/11795514221098403 - DOI - PMC - PubMed
    1. Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers MH. The pathophysiology of gestational diabetes mellitus. Int. J. Mol. Sci. (2018) 19. doi: 10.3390/ijms19113342 - DOI - PMC - PubMed
    1. Zhang S, Liu H, Li N, Dong W, Li W, Wang L, et al. . Relationship between gestational body mass index change and the risk of gestational diabetes mellitus: a community-based retrospective study of 41,845 pregnant women. BMC Pregnancy Childbirth. (2022) 22. doi: 10.1186/s12884-022-04672-5 - DOI - PMC - PubMed
    1. Yong HY, Mohd Shariff Z, Mohd Yusof BN, Rejali Z, Tee YYS, Bindels J, et al. . Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus. Sci. Rep. (2020) 10. doi: 10.1038/s41598-020-65251-2 - DOI - PMC - PubMed

LinkOut - more resources