Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 18;56(3):375-383.
doi: 10.19723/j.issn.1671-167X.2024.03.001.

[A ssociations of short-term ambient particulate matter exposure and MTNR1B gene with triglyceride-glucose index: A family-based study]

[Article in Chinese]
Huangda Guo  1 , Hexiang Peng  1 , Siyue Wang  1 , Tianjiao Hou  1 , Yixin Li  1 , Hanyu Zhang  1 , Mengying Wang  2   3 , Yiqun Wu  1   3 , Xueying Qin  1   3 , Xun Tang  1   3 , Jing Li  1   3 , Dafang Chen  1   3 , Yonghua Hu  1   3 , Tao Wu  1   3
Affiliations

[A ssociations of short-term ambient particulate matter exposure and MTNR1B gene with triglyceride-glucose index: A family-based study]

[Article in Chinese]
Huangda Guo et al. Beijing Da Xue Xue Bao Yi Xue Ban. .

Abstract
in English, Chinese

Objective: To explore the effects of short-term particulate matter (PM) exposure and the melatonin receptor 1B (MTNR1B) gene on triglyceride-glucose (TyG) index utilizing data from Fang-shan Family-based Ischemic Stroke Study in China (FISSIC).

Methods: Probands and their relatives from 9 rural areas in Fangshan District, Beijing, were included in the study. PM data were obtained from fixed monitoring stations of the National Air Pollution Monitoring System. TyG index was calculated by fasting triglyceride and glucose concentrations. The associations of short-term PM exposure and rs10830963 polymorphism of the MTNR1B gene with the TyG index were assessed using mixed linear models, in which covariates such as age, sex, and lifestyles were adjusted for. Gene-environment inter-action analysis was furtherly performed using the maximum likelihood methods to explore the potential effect modifier role of rs10830963 polymorphism in the association of PM with TyG index.

Results: A total of 4 395 participants from 2 084 families were included in the study, and the mean age of the study participants was (58.98±8.68) years, with 53. 90% females. The results of association analyses showed that for every 10 μg/m3 increase in PM2.5 concentration, TyG index increased by 0.017 (95%CI: 0.007-0.027), while for per 10 μg/m3 increment in PM10, TyG index increased by 0.010 (95%CI: 0.003-0.017). And the associations all had lagged effects. In addition, there was a positive association between the rs10830963 polymorphism and the TyG index. For per increase in risk allele G, TyG index was elevated by 0.040 (95%CI: 0.004-0.076). The TyG index was 0.079 (95%CI: 0.005-0.152) higher in carriers of the GG genotype compared with carriers of the CC genotype. The interaction of rs10830963 polymorphism with PM exposure had not been found to be statistically significant in the present study.

Conclusion: Short-term exposure to PM2.5 and PM10 were associated with higher TyG index. The G allele of rs10830963 polymorphism in the MTNR1B gene was associated with the elevated TyG index.

目的: 利用北京房山家系队列研究资料, 探索短期大气颗粒物(particulate matter, PM)暴露和褪黑素受体1B(melatonin receptor 1 B, MTNR1B)基因多态性对甘油三酯-葡萄糖(triglyceride-glucose, TyG)指数的影响。

方法: 纳入来自北京市房山区9个乡镇的先证者及其亲属作为研究对象, 使用混合线性模型评估短期PM暴露和MTNR1B基因rs10830963位点多态性与TyG指数的关联，进一步利用最大似然法进行基因-环境交互作用分析, 探索rs10830963位点多态性在PM与TyG指数关联中的效应修饰作用。

结果: 共纳入来自2 084个家系的4 395名参与者，研究对象平均年龄(58.98 +8.68)岁, 女性占比53.90%。关联分析结果显示, PM2.5浓度每升高10 μg/m3, TyG指数升高0.017(95% Cl: 0.007~ 0.027), 而PM10。每升高10 μg/m3, TyG指数升高0.010(95% CI: O. 003 ~0.017), 且关联均存在滞后效应。此外, rs10830963位点与TyG指数存在阳性关联。每增加一个风险等位基因G, TyG指数升高0.040(95% CI: 0. 004 ~0.076)。与CC基因型携带者相比, GG基因型携带者的TyG指数高0.079(95% CI: 0. 005 ~0. 152)。未发现该位点多态性与PM暴露的交互作用具有统计学意义。

结论: PM2.5和PM10。短期暴露与较高的TyG指数相关, MTNR1B基因的rs10830963位点G等位基因与TyG指数升高相关联。

Keywords: Family-based study; Inhalation exposure; MTNR1B gene; Particulate matter; Triglyceride-glucose index.

PubMed Disclaimer

Conflict of interest statement

利益冲突 所有作者均声明不存在利益冲突。

Figures

图 1
图 1
大气颗粒物(PM2.5和PM10)与TyG的关联 Association of particulate matter (PM2.5, PM10) and TyG index
图 2
图 2
大气颗粒物(PM2.5和PM10)与rs10830963位点的交互作用分析结果 Interaction analysis of particulate matter (PM2.5, PM10) with rs10830963
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Xiao D, Sun H, Chen L, et al. Assessment of six surrogate insulin resistance indexes for predicting cardiometabolic multimorbidity incidence in Chinese middle-aged and older populations: Insights from the China health and retirement longitudinal study. Diabetes Metab Res Rev. 2024;40(1):e3764. doi: 10.1002/dmrr.3764. - DOI - PubMed
    1. Guerrero-Romero F, Simental-Mendía LE, González-Ortiz M, et al. The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. J Clin Endocrinol Metab. 2010;95(7):3347–3351. doi: 10.1210/jc.2010-0288. - DOI - PubMed
    1. Zhang J, Yin B, Xi Y, et al. Triglyceride-glucose index is a risk factor for breast cancer in China: A cross-sectional study. Lipids Health Dis. 2024;23(1):29. doi: 10.1186/s12944-024-02008-0. - DOI - PMC - PubMed
    1. Hao B, Lyu L, Xu J, et al. The relationship between triglyceride-glucose index and prospective key clinical outcomes in patients hospitalised for coronary artery disease. Cardiovasc Diabetol. 2024;23(1):40. doi: 10.1186/s12933-024-02132-2. - DOI - PMC - PubMed
    1. Su W, Wang J, Chen K, et al. A higher TyG index level is more likely to have enhanced incidence of T2DM and HTN comorbidity in elderly Chinese people: A prospective observational study from the reaction study. Diabetol Metab Syndr. 2024;16(1):29. doi: 10.1186/s13098-024-01258-3. - DOI - PMC - PubMed

Publication types