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. 2024 Oct;57(10):1395-1403.
doi: 10.1111/iej.14109. Epub 2024 Jun 12.

Elevated serum hepatic transaminases in apical periodontitis individuals

María José Bordagaray  1   2 , Elizabeth Pellegrini  1 , Mauricio Garrido  2 , Patricia Hernández-Ríos  2 , Thomas Villalobos  1 , Alejandra Fernández  3 , Marcela Hernández  1   4
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Elevated serum hepatic transaminases in apical periodontitis individuals

María José Bordagaray et al. Int Endod J. 2024 Oct.

Abstract

Aim: Apical periodontitis (AP) is the chronic inflammation of the periradicular tissues in response to root canal infection. Whilst AP has been linked with systemic inflammation and noncommunicable diseases, its potential association with nonalcoholic fatty liver disease (NAFLD) is unknown. We aimed to evaluate the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels as surrogate markers of hepatic injury, and the systemic inflammatory burden in otherwise healthy individuals with and without AP diagnosis.

Methodology: Cross-sectional study. Individuals with AP (n = 30) and healthy controls (n = 29) were recruited. The number, mean diameter (mm) and periapical index of the apical lesions of endodontic origin (ALEO) were assessed. ALT and AST levels (pg/mL) were measured through enzyme-linked immunosorbent assays. The serum levels of TNF-α, IL-4, IL-9, IL-10, IL-17A and IL-22 were evaluated by Multiplex assay. Inferential analysis was performed using t-test or Mann-Whitney tests according to data distribution and linear regression models. Data were analysed with StataV16 (p < .05).

Results: ALT and AST levels were significantly higher in individuals with AP compared to controls (p < .05). Serum inflammatory biomarkers showed no significant differences between the study groups. Bivariate and multivariate analyses confirmed that AP diagnosis was independently associated with ALT and AST elevations (p < .05). Additionally, the number of ALEO positively influenced AST levels (p = .002). IL-22 on the other hand, was associated with reduced ALT levels (p = .043).

Conclusion: AP is associated with higher serum hepatic transaminases ALT and AST, potentially contributing to NAFLD physiopathology in young adults.

Keywords: alanine transaminase; aspartate aminotransferase; periapical periodontitis.

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References

REFERENCES

    1. Ahmad, A., Furuta, M., Shinagawa, T., Takeuchi, K., Takeshita, T., Shimazaki, Y. et al. (2015) Association of periodontal status with liver abnormalities and metabolic syndrome. Journal of Oral Science, 57(4), 335–343.
    1. Albrecht, J.H. & Hansen, L.K. (1999) Cyclin D1 promotes mitogen‐independent cell cycle progression in hepatocytes. Cell Growth & Differentiation, 10(6), 397–404.
    1. Alvarado, M.E., Garmendia, M.L., Acuña, G., Santis, R. & Arteaga, O. (2009) Validez y confiabilidad de la versión chilena del Alcohol Use Disorders Identification Test (AUDIT). Revista Médica de Chile, 137, 1463–1468.
    1. Alvarez, C., Monasterio, G., Cavalla, F., Córdova, L.A., Hernández, M., Heymann, D. et al. (2019) Osteoimmunology of oral and maxillofacial diseases: translational applications based on biological mechanisms. Frontiers in Immunology, 10, 1664.
    1. Bordagaray, M.J., Fernández, A., Garrido, M., Astorga, J., Hoare, A. & Hernández, M. (2021) Systemic and Extraradicular bacterial translocation in apical periodontitis. Frontiers in Cellular and Infection Microbiology, 11, 649925.

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