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Case Reports
. 2024 Jun 12;62(6):e0163823.
doi: 10.1128/jcm.01638-23. Epub 2024 Jun 12.

The Brief Case: Yeast, chlamydospores, and hyphae-a case of disseminated mucormycosis

Nicole E Putnam  1 , Khadija Tayabali  2 , Justine R Yu  1 , Isabel Decolin  3 , Anna F Lau  3 , William Twaddell  1 , Katya Prakash  4 , J Kristie Johnson  1
Affiliations
Case Reports

The Brief Case: Yeast, chlamydospores, and hyphae-a case of disseminated mucormycosis

Nicole E Putnam et al. J Clin Microbiol. .
No abstract available

Keywords: Mucor; dimorphic fungi; fungemia; mucormycosis; mycology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig 1
Fig 1
Positive blood culture with M. velutinosus shows pleomorphic fungal elements. Positive blood subculture with rapid, cottony mold growth over bacterial colonies after 1 day of incubation at 37°C on TSA with sheep blood (A). Gram stain from positive blood culture bottles shows pauci-septate, ribbon-like hyphae characteristic of Mucor spp. at 1,000× (B). Calcofluor white was used to stain and image positive blood cultures and shows pleomorphic yeast and hyphal elements, including multipolar budding yeast (C) and 90° angle branching, terminal chlamydospores, and successive chlamydospores (D) at 400×.
Fig 2
Fig 2
Histologic assessment of cutaneous lesions showing angioinvasion. Disseminated, purpuric cutaneous lesions on extremities (A). Representative histological section of the 63-year-old patient’s skin punch biopsy, showing separation of the epidermis as well as fungal elements (black arrows) present in the dermal stroma and small blood vessels. Hematoxylin and eosin (H&E), 10× magnification (B). Representative histologic sections from the patient’s skin showing invasion of fungal elements into the vessel walls and lumen near the resection margin (inked black). H&E, 10× magnification (C). Higher magnification shows broad, pauci-septate hyphae branching at 90° angles (black arrow), a morphology characteristic of Mucor spp. Note the presence of fungal elements approaching and invading the blood vessels as well as a peripheral nerve (blue arrow). H&E, 20× magnification (D).
See this image and copyright information in PMC

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