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. 2024 Jun 13;390(22):2127-2128.
doi: 10.1056/NEJMc2314441.

Near-Universal Resistance to Macrolides of Treponema pallidum in North America

Nicole A P Lieberman  1 , Tara B Reid  1 , Chase A Cannon  1 , B Ethan Nunley  1 , Anna Berzkalns  2 , Stephanie E Cohen  3 , Lori M Newman  4 , Sol Aldrete  5 , Linda H Xu  6 , Clinton P Thornlund  6 , Kevin Pettus  7 , Stephanie Lundy  7 , Michael Kron  5 , Olusegun O Soge  6 , Kimberly Workowski  8 , Charlotte Perlowski  9 , Edward W Hook 3rd  10 , Jodie A Dionne  10 , Matthew R Golden  6 , Joshua A Lieberman  6 , Min-Kuang Lee  11 , Muhammad Morshed  11 , Prenilla Naidu  12 , Weiping Cao  7 , Allan Pillay  7 , Lorenzo Giacani  6 , Alexander L Greninger  6
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Near-Universal Resistance to Macrolides of Treponema pallidum in North America

Nicole A P Lieberman et al. N Engl J Med. .
No abstract available

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Figures

Figure 1.
Figure 1.. Azithromycin Resistance in Tested Treponema pallidum Strains.
Of the 604 strains for which genotypic susceptibility to macrolides could be determined, 599 were resistant (584 through the A2058G mutation and 15 through the A2059G mutation) (Panel A). A single-nucleotide polymorphism (SNP)–only maximum-likelihood phylogenetic tree (Panel B) was constructed with the use of a subset of 54 strains with sufficient sequencing data. Tips with gray fill indicate resistance to azithromycin, and black fill indicates sensitivity. Nichols and SS14 reference sequences are included as white squares.
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References

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