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Randomized Controlled Trial
. 2024 Jul;28(7):100289.
doi: 10.1016/j.jnha.2024.100289. Epub 2024 Jun 11.

Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention

Cristina Galarregui  1 , Santiago Navas-Carretero  2 , M Angeles Zulet  3 , Carlos J González-Navarro  1 , J Alfredo Martínez  4 , Begoña de Cuevillas  1 , Helena Marcos-Pasero  5 , Elena Aguilar-Aguilar  5 , Guillermo Reglero  6 , Ana Ramirez de Molina  7 , Paloma Chausa  8 , Jose M Iniesta  8 , M Elena Hernando  9 , Enrique J Gómez  9 , Alejandro Garcia-Rudolph  10 , Alberto García-Molina  10 , Viviana Loria-Kohen  5 , Itziar Abete  3
Affiliations
Randomized Controlled Trial

Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention

Cristina Galarregui et al. J Nutr Health Aging. 2024 Jul.

Abstract

Objectives: Innovative precision dietary procedures are required to promote healthy aging. This study aimed to evaluate the effects of a personalised strategy based on the inclusion of individualised foods and digital tools on overall health status and quality of life within a follow-up of 3 months in older adults with overweight or obesity.

Methods: 127 men and women aged between 50 and 80 years with overweight/obesity participated in the study-between January 2020 and September 2020 at the Center for Nutrition Research-University of Navarra and IMDEA-ALIMENTACIÓN-and were randomly assigned to a usual-care group (standard recommendations) or precision group (precision nutrition strategy based on the inclusion of individualised foods and a mobile application). Anthropometry, body fat percentage, biochemical parameters, diet, and quality of life (SF-36 Health Survey) were assessed at baseline and after 3 months.

Results: Both strategies were found to improve overall metabolic health; however, the precision approach demonstrated significantly better outcomes. The precision strategy reduced body weight at 3 months (-4.3 kg; p < 0.001) with significant improvements in body fat percentage, blood pressure and general metabolic health (glycated haemoglobin; alanine aminotransferase; aspartate aminotransferase; hepatic steatosis index) in comparison with the standard recommendations. The precision approach significantly enhanced the quality of life (SF-36) of individuals, with additional improvements in emotional well-being (p = 0.024) and vitality (p = 0.008). Adherence to the Mediterranean diet was significantly associated with a higher quality of life and vitality.

Conclusion: These results support the benefit of precision nutrition approaches for promoting healthy aging and emotional well-being, enhancing the quality of life in aging populations, during the COVID-19 pandemic.

Keywords: Chronic diseases; Functional foods; Healthy aging; Precision nutrition; Quality of life.

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Figures

Fig. 1
Fig. 1
Flowchart of the participants in the intervention study.
See this image and copyright information in PMC

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