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Comment
. 2024 Jun 11;57(6):1187-1189.
doi: 10.1016/j.immuni.2024.05.015.

Claudin 18 turns up the heat in cancer

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Claudin 18 turns up the heat in cancer

Jialin Zhang et al. Immunity. .
Free article

Abstract

A major barrier to antitumor immunity in solid tumors is T cell exclusion. In this issue of Immunity, De Sanctis et al.1 elucidate how CLDN18 on pancreatic and lung cancer cells enhances infiltration, immunological synapse formation, and activation of cytotoxic T lymphocytes.

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Declaration of interests The authors have no competing interests to report.

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