Claudin 18 turns up the heat in cancer
- PMID: 38865963
- DOI: 10.1016/j.immuni.2024.05.015
Claudin 18 turns up the heat in cancer
Abstract
A major barrier to antitumor immunity in solid tumors is T cell exclusion. In this issue of Immunity, De Sanctis et al.1 elucidate how CLDN18 on pancreatic and lung cancer cells enhances infiltration, immunological synapse formation, and activation of cytotoxic T lymphocytes.
Copyright © 2024 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors have no competing interests to report.
Comment on
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Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer.Immunity. 2024 Jun 11;57(6):1378-1393.e14. doi: 10.1016/j.immuni.2024.04.021. Epub 2024 May 14. Immunity. 2024. PMID: 38749447
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