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. 2024 Jun 11;57(6):1195-1214.
doi: 10.1016/j.immuni.2024.05.010.

Challenges and opportunities in long COVID research

Rebecca E Hamlin  1 , Catherine A Blish  2
Affiliations

Challenges and opportunities in long COVID research

Rebecca E Hamlin et al. Immunity. .

Abstract

Long COVID (LC) is a condition in which patients do not fully recover from the initial SARS-CoV-2 infection but rather have persistent or new symptoms for months to years following the infection. Ongoing research efforts are investigating the pathophysiologic mechanisms of LC and exploring preventative and therapeutic treatment approaches for patients. As a burgeoning area of investigation, LC research can be structured to be more inclusive, innovative, and effective. In this perspective, we highlight opportunities for patient engagement and diverse research expertise, as well as the challenges of developing definitions and reproducible studies. Our intention is to provide a foundation for collaboration and progress in understanding the biomarkers and mechanisms driving LC.

Keywords: PASC; long COVID; long-haul COVID; post-COVID conditions; post-acute sequelae of SARS-CoV-2 infection.

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Conflict of interest statement

Declaration of interests C.A.B. is a scientific advisory board member of ImmuneBridge, DeepCell, Inc., and Qihan Bio on topics unrelated to this manuscript.

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