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Observational Study
. 2024 Jun 12;14(6):e081933.
doi: 10.1136/bmjopen-2023-081933.

Incidence, management and outcomes in hepatic artery complications after paediatric liver transplantation: protocol of the retrospective, international, multicentre HEPATIC Registry

Weihao Li  1 , Hubert P J van der Doef  2 , Barbara E Wildhaber  3 , Paolo Marra  4   5 , Michela Bravi  6 , Domenico Pinelli  7 , Julia Minetto  8 , Marcelo Dip  8 , Sergio Sierre  9 , Martin de Santibañes  10 , Victoria Ardiles  10 , Jimmy Walker Uno  10 , Winita Hardikar  11 , Sue Bates  11 , Lynette Goh  11 , Denise Aldrian  12 , Jonathan Seisenbacher  12 , Georg F Vogel  12   13 , Joao Seda Neto  14 , Eduardo Antunes da Fonseca  14 , Carolina Magalhães Costa  14 , Cristina T Ferreira  15 , Luiza S Nader  16 , Marco A Farina  16 , Khaled Z Dajani  17 , Alessandro Parente  17 , David L Bigam  17 , Ting-Bo Liang  18 , Xueli Bai  18 , Wei Zhang  18 , Lucie Gonsorčíková  19 , Jiří Froněk  20 , Šimon Bohuš  19 , Stéphanie Franchi-Abella  21 , Emmanuel Gonzales  22 , Florent Guérin  23 , Norman Junge  24 , Ulrich Baumann  24 , Nicolas Richter  25 , Steffen Hartleif  26 , Ekkehard Sturm  26 , Muthukumarassamy Rajakannu  27 , Kumar Palaniappan  27 , Mohamed Rela  27 , Arti Pawaria  28 , Haritha Rajakrishnan  29 , Sudhindran Surendran  29 , Mukesh Kumar  30 , Shaleen Agarwal  30 , Subhash Gupta  30 , Sonal Asthana  31 , Vaishnavi Bandewar  31 , Karthik Raichurkar  31 , Marco Spada  32 , Lidia Monti  33 , Tommaso Alterio  34 , Yusuke Yanagi  35 , Hajime Uchida  36 , Ryuji Komine  35 , Helen Evans  37 , Peter Carr-Boyd  38 , David Duncan  39 , Marek Stefanowicz  40 , Julita Latka-Grot  40 , Adam Kolesnik  40 , Dieter C Broering  41 , Dimitri A Raptis  41 , Kris Ann H Marquez  41 , Vidyadhar Mali  42 , Marion Aw  43 , Marisa Beretta  44 , Francisca Van der Schyff  45 , Jesús Quintero-Bernabeu  46 , Maria Mercadal-Hally  46 , Mauricio Larrarte K  46 , Ane M Andres  47 , Francisco Hernandez-Oliveros  47 , Esteban Frauca  48 , Thomas Casswall  49 , Carl Jorns  50 , Martin Delle  51 , Girish Gupte  52 , Khalid Sharif  52 , Simon McGuirk  53 , Riccardo Superina  54 , Juan Carlos Caicedo  55 , Catalina Jaramillo  56 , Leandra Bitterfeld  57 , Zachary Kastenberg  58 , Amit A Shah  59 , Bryanna Domenick  59 , Michael R Acord  60 , George V Mazariegos  61 , Kyle Soltys  61 , Joseph DiNorcia  62 , Swanti Antala  62 , Sander S Florman  62 , Bettina M Buchholz  63 , Uta Herden  63 , Lutz Fischer  63 , Rudi A J O Dierckx  64 , Hermien Hartog  65 , Reinoud P H Bokkers  66
Affiliations
Observational Study

Incidence, management and outcomes in hepatic artery complications after paediatric liver transplantation: protocol of the retrospective, international, multicentre HEPATIC Registry

Weihao Li et al. BMJ Open. .

Abstract

Introduction: Hepatic artery complications (HACs), such as a thrombosis or stenosis, are serious causes of morbidity and mortality after paediatric liver transplantation (LT). This study will investigate the incidence, current management practices and outcomes in paediatric patients with HAC after LT, including early and late complications.

Methods and analysis: The HEPatic Artery stenosis and Thrombosis after liver transplantation In Children (HEPATIC) Registry is an international, retrospective, multicentre, observational study. Any paediatric patient diagnosed with HAC and treated for HAC (at age <18 years) after paediatric LT within a 20-year time period will be included. The primary outcomes are graft and patient survivals. The secondary outcomes are technical success of the intervention, primary and secondary patency after HAC intervention, intraprocedural and postprocedural complications, description of current management practices, and incidence of HAC.

Ethics and dissemination: All participating sites will obtain local ethical approval and (waiver of) informed consent following the regulations on the conduct of observational clinical studies. The results will be disseminated through scientific presentations at conferences and through publication in peer-reviewed journals.

Trial registration number: The HEPATIC registry is registered at the ClinicalTrials.gov website; Registry Identifier: NCT05818644.

Keywords: hepatology; interventional radiology; paediatric transplant surgery.

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Conflict of interest statement

Competing interests: None declared.

References

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