Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Aug;30(8):702-704.
doi: 10.1016/j.molmed.2024.05.018. Epub 2024 Jun 11.

Beyond the danger signal: RNA aggregates orchestrate immunotherapy

Quazi T H Shubhra  1 , Tivadar Feczkó  2 , Qiang Cai  3
Affiliations
Review

Beyond the danger signal: RNA aggregates orchestrate immunotherapy

Quazi T H Shubhra et al. Trends Mol Med. 2024 Aug.

Abstract

Mendez-Gomez et al. recently demonstrated the transformative potential of RNA-lipid particle aggregates (RNA-LPAs) in immunotherapy. By reprogramming the tumor microenvironment (TME) and potentiating antitumor immunity, RNA-LPAs target primary tumors and elicit robust systemic immunity. This innovative platform holds promise for translating preclinical success into tangible clinical benefits.

Keywords: cancer vaccine; immunotherapy; lipid particle aggregates (LPAs); mRNA; tumor microenvironment (TME).

PubMed Disclaimer

Conflict of interest statement

Declaration of Interests The authors declare no competing interests.

Similar articles

  • RNA aggregates harness the danger response for potent cancer immunotherapy.
    Mendez-Gomez HR, DeVries A, Castillo P, von Roemeling C, Qdaisat S, Stover BD, Xie C, Weidert F, Zhao C, Moor R, Liu R, Soni D, Ogando-Rivas E, Chardon-Robles J, McGuiness J, Zhang D, Chung MC, Marconi C, Michel S, Barpujari A, Jobin GW, Thomas N, Ma X, Campaneria Y, Grippin A, Karachi A, Li D, Sahay B, Elliott L, Foster TP, Coleman KE, Milner RJ, Sawyer WG, Ligon JA, Simon E, Cleaver B, Wynne K, Hodik M, Molinaro AM, Guan J, Kellish P, Doty A, Lee JH, Massini T, Kresak JL, Huang J, Hwang EI, Kline C, Carrera-Justiz S, Rahman M, Gatica S, Mueller S, Prados M, Ghiaseddin AP, Silver NL, Mitchell DA, Sayour EJ. Mendez-Gomez HR, et al. Cell. 2024 May 9;187(10):2521-2535.e21. doi: 10.1016/j.cell.2024.04.003. Epub 2024 May 1. Cell. 2024. PMID: 38697107 Free PMC article.
  • mRNA aggregates harness danger response for potent cancer immunotherapy.
    Mendez-Gomez HR, DeVries A, Castillo P, Stover BD, Qdaisat S, Von Roemeling C, Ogando-Rivas E, Weidert F, McGuiness J, Zhang D, Chung MC, Li D, Zhang C, Marconi C, Campaneria Y, Chardon-Robles J, Grippin A, Karachi A, Thomas N, Huang J, Milner R, Sahay B, Sawyer WG, Ligon JA, Silver N, Simon E, Cleaver B, Wynne K, Hodik M, Molinaro A, Guan J, Kellish P, Doty A, Lee JH, Carrera-Justiz S, Rahman M, Gatica S, Mueller S, Prados M, Ghiaseddin A, Mitchell DA, Sayour EJ. Mendez-Gomez HR, et al. medRxiv [Preprint]. 2023 Mar 17:2023.03.12.23287108. doi: 10.1101/2023.03.12.23287108. medRxiv. 2023. Update in: Cell. 2024 May 9;187(10):2521-2535.e21. doi: 10.1016/j.cell.2024.04.003. PMID: 36993772 Free PMC article. Updated. Preprint.
  • Systemic immunity in cancer.
    Hiam-Galvez KJ, Allen BM, Spitzer MH. Hiam-Galvez KJ, et al. Nat Rev Cancer. 2021 Jun;21(6):345-359. doi: 10.1038/s41568-021-00347-z. Epub 2021 Apr 9. Nat Rev Cancer. 2021. PMID: 33837297 Free PMC article. Review.
  • Nanoengineered Platform-Based Microenvironment-Triggered Immunotherapy in Cancer Treatment.
    Dhas N, Kudarha R, Kulkarni S, Soman S, Navti PD, Kulkarni J, Roy AA, Colaco V, Raychaudhuri R, Gupta A, Pardeshi C, Bari D, Tiwari R, Patel J, Moorkoth S, Mutalik S. Dhas N, et al. Front Biosci (Landmark Ed). 2024 Oct 8;29(10):349. doi: 10.31083/j.fbl2910349. Front Biosci (Landmark Ed). 2024. PMID: 39473401 Review.
  • Metabolic reprogramming of the tumor microenvironment to enhance immunotherapy.
    Lim SA. Lim SA. BMB Rep. 2024 Sep;57(9):388-399. doi: 10.5483/BMBRep.2024-0031. BMB Rep. 2024. PMID: 38919017 Free PMC article. Review.
See all similar articles

Cited by

LinkOut - more resources