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. 2025 Jan;27(1):117-125.
doi: 10.1007/s12094-024-03550-0. Epub 2024 Jun 13.

Prognostic risk stratification value of MACC1 expression in patients with gastric cancer

Xia Zhang #  1   2 , Xing-Jun Feng #  3 , Qiu-Yue Han  1   2 , Jian-Gang Zhang  1   2 , Wei-Hua Yan  4   5 , Aifen Lin  6   7
Affiliations

Prognostic risk stratification value of MACC1 expression in patients with gastric cancer

Xia Zhang et al. Clin Transl Oncol. 2025 Jan.

Abstract

Background: The prognostic significance of metastasis-associated in colon cancer-1 (MACC1) has been explored in a variety of malignancies. However, its clinical relevance in patients with gastric cancer (GC) is limited, also remains controversial.

Method: In this study, we retrospectively evaluated the prognostic value of lesion MACC1 expression in 347 GC patients. Lesion MACC1 expression was analyzed with immunohistochemistry and grouped as MACC1low (n = 172) and MACC1high (n = 175) cases.

Results: Data revealed that the degree of MACC1 expression is not related to patient sex, age and disease stage (all p > 0.05). Survival analysis showed that only post-operation advanced pT (p = 0.018), pN (p < 0.001), pM (p = 0.001) and AJCC stages (p < 0.001) are significantly associated with shorter survival, while no obvious difference was observed between MACC1low and MACC1high cases (p = 0.158). However, we found that survival for female (p = 0.032), older (p = 0.028), and early disease stage (pT stage I + II, p = 0.033) patients with MACC1high are remarkably worse than those with MACC1low.

Conclusion: In summary, our findings revealed that, though MACC1 expression is not associated with the survival of the whole cohort, the prognostic risk stratification value of lesion MACC1 expression in subgroups of patients with gastric cancer should be noted.

Keywords: Gastric cancer; MACC1; Prognosis; Survival.

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Conflict of interest statement

Declarations. Conflict of interest: All authors declare no conflict of interest. Ethical approval and consent to participate: This study protocol was reviewed and approved by Ethics Board of Taizhou Hospital of Zhejiang Province, China (K2D200824), and written informed consent from each participant was obtained prior to the surgery.

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