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. 2024 Jun 12;23(1):184.
doi: 10.1186/s12944-024-02174-1.

Association between body roundness index and overactive bladder: results from the NHANES 2005-2018

Yujun Zhang #  1   2 , Jingjing Song #  1   3 , Benjie Li #  1   4 , Yunhao Wu  5 , Shengjun Jia  5 , Hongxin Shu  6 , Fang Liu  7 , Xiaorong Yang  8   9   10
Affiliations

Association between body roundness index and overactive bladder: results from the NHANES 2005-2018

Yujun Zhang et al. Lipids Health Dis. .

Abstract

Background and aim: An increasing amount of research has indicated obesity greatly affects individuals with overactive bladder (OAB). However, traditional anthropometric methods present challenges in accurately assessing the likelihood of OAB. Hence, this study's objective was to identify the correlation between the body roundness index (BRI) and OAB.

Methods: The research included 12,401 individuals who participated in the National Health and Nutrition Examination Survey spanning 2005-2018. The correlation between BRI and OAB was explored by using weighted multiple logistic regression and weighted restricted cubic spline (RCS). Subgroup analyses showed the associations based on different population types. The study also analyzed the predictive capability of various anthropometric indices, including BRI, body mass index, waist circumference, and weight, in assessing the likelihood of OAB through Receiver-operating characteristic (ROC) curves.

Results: An independent positive correlation between OAB and BRI was identified after adjusting for potential confounders in weighted multivariate logistic models[odds ratio (OR) = 1.15, 95% confidence interval (CI), 1.12-1.17]. Weighted RCS analysis found a positive dose-response correlation between OAB and BRI. The effect size of BRI on OAB remained stable across all prespecified subgroups (all P for interactions > 0.05). In ROC analysis, BRI showed better discriminatory ability for OAB compared with other anthropometric measures for both genders (all P < 0.01). The best BRI cutoff for predicting OAB was lower for men (5.151) than for women (5.383), suggesting that men were more susceptible to changes in BRI than women.

Conclusions: This study demonstrated that a raised BRI is correlated with a higher likelihood of OAB. Due to the effectiveness and non-invasiveness of BRI in predicting OAB, it is expected to become the preferred method for early detection and management strategies.

Keywords: Body roundness index; Cross-sectional study; NHANES; Overactive bladder.

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Conflict of interest statement

All authors declare that the study was conducted without any conflicts.

Figures

Fig. 1
Fig. 1
Flow diagram of study cohort selection
Fig. 2
Fig. 2
Weighted multivariate logistic regression analysis of BRI and overactive bladder
Fig. 3
Fig. 3
Nonlinear correlation between OAB and BRI
Fig. 4
Fig. 4
The association between OAB and BRI in various subgroups
Fig. 5
Fig. 5
Receiver operating characteristic (ROC) curve analysis for predicting overactive bladder
See this image and copyright information in PMC

References

    1. White N, Iglesia CB. Overactive bladder. Obstet Gynecol Clin North Am. 2016;43(1):59–68. doi: 10.1016/j.ogc.2015.10.002. - DOI - PubMed
    1. Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S, et al. Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. Eur Urol. 2006;50(6):1306–14. doi: 10.1016/j.eururo.2006.09.019. - DOI - PubMed
    1. Wang Y, Xu K, Hu H, Zhang X, Wang X, Na Y, et al. Prevalence, risk factors, and impact on health related quality of life of overactive bladder in China. Neurourol Urodyn. 2011;30(8):1448–55. doi: 10.1002/nau.21072. - DOI - PubMed
    1. Irwin DE, Kopp ZS, Agatep B, Milsom I, Abrams P. Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU Int. 2011;108(7):1132–8. doi: 10.1111/j.1464-410X.2010.09993.x. - DOI - PubMed
    1. Sexton CC, Coyne KS, Vats V, Kopp ZS, Irwin DE, Wagner TH. Impact of overactive bladder on work productivity in the United States: results from EpiLUTS. Am J Manag Care. 2009;15(4 Suppl):S98–107. - PubMed