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. 2024 Jun 12;43(1):83.
doi: 10.1186/s41043-024-00577-5.

Global research trends on the relationship between IBD and CRC: a bibliometric analysis from 2000 to 2023

Hao Zhang #  1 , Huiru Xin #  2 , Mengqi Zhao #  3 , Chenyang Bi  1 , Yafei Xiao  1 , Yifan Li  1 , Changjiang Qin  4
Affiliations

Global research trends on the relationship between IBD and CRC: a bibliometric analysis from 2000 to 2023

Hao Zhang et al. J Health Popul Nutr. .

Abstract

Objective: This study aimed to conduct a bibliometric analysis of research articles on the relationship between inflammatory bowel disease (IBD) and colorectal cancer (CRC) using CiteSpace to summarize the current research status, hotspots, and trends in this field and present the results visually.

Method: Research articles on the relationship between IBD and CRC published from 2000 to 2023 and in English were selected from the Web of Science Core Collection (Woscc) database. The articles were downloaded as "full record and references". CiteSpace was used to conduct cooperative, cluster, co-citation, and burst analyses.

Results: The literature search revealed 4244 articles; of which, 5 duplicates were removed, resulting in the inclusion of 4239 articles in this study. The United States of America had the highest number of publications, with Mayo Clinic and Harvard University being the most active institutions, and Bas Oldenburg being the most active author. Collaboration among core authors was inadequate. JA Eaden was the most cited author, and CRC was the most common keyword. Burst analysis indicated that Sun Yat-sen University might be one of the institutions with a large contribution to this research field in the future. Cluster analysis showed that earlier research focused more on microsatellite instability, whereas "gut microbiota" and "oxidative stress" are considered current research hotspots and trends.

Conclusion: At present, the primary focus areas of research are "gut microbiota" and "oxidative stress". With the improvement of healthcare policies and standards, regular endoscopic monitoring of patients with IBD has become an indispensable diagnostic and therapeutic practice. More drugs will be developed to reduce the risk of progression from IBD to CRC. The findings of this study provide valuable insights into the relationship between IBD and CRC for researchers in the same field.

Keywords: Bibliometric; CRC; CiteSpace; IBD; WoSCC.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Visualization Analysis of Countries/Regions. (A) Distribution of countries in terms of publications. (B) Network diagram showing country links; time slice = 6, top 30 per slice; N = 40, E = 90. (C) Top 10 most productive countries. (D) Top 15 countries in publishing research on the association between IBD and CRC with burst period after 2000
Fig. 2
Fig. 2
Visualization Analysis of Research Institutions, Authors and reference. (A) Network diagram showing institution links; Slice length = 1, Top 10 per slice, N = 246, E = 333. (B) Network diagram showing literature co-citations link; Slice length = 1; Top 30 per slice, N = 685, E = 3036. (C) Network diagram showing author links; Slice length = 1; Top 10 per slice, N = 742, E = 187. (D) Network diagram showing co-author links; Slice length = 1; Top 30 per slice, N = 213, E = 609. (E) Top 15 institutions in publishing research the association between IBD and CRC with burst period after 2000. (F) Top 15 articles related to research the association between IBD and CRC with burst period after 2000
Fig. 3
Fig. 3
Analysis of the characteristics of Co-citation clustering and Keywords (A) Co-cited References Clustering Diagram. (B) Co-cited References Clustering Timeline Diagram. (C) Keyword Co-occurrence Network Diagram and Keyword Clustering. (D) Top 15 keywords related to research the association between IBD and CRC with burst period after 2000
See this image and copyright information in PMC

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