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. 2022 Jun 30;1(3):e16.
doi: 10.1002/pcn5.16. eCollection 2022 Sep.

Early menarche and adult major depressive disorder among Japanese women: The role of childhood traumatic experience and socioeconomic conditions in young adulthood

Maki Umeda  1 , Norito Kawakami  2 , Haruki Shimoda  3 , Karin Miyamoto  4 , Hanako Ishikawa  2 , Hisateru Tachimori  5 , Tadashi Takeshima  6
Affiliations

Early menarche and adult major depressive disorder among Japanese women: The role of childhood traumatic experience and socioeconomic conditions in young adulthood

Maki Umeda et al. PCN Rep. .

Abstract

Aim: The aim of this study is to examine the long-term impact of early menarche with adult depression, and to assess whether this association was explained by childhood traumatic experience and socioeconomic condition in early adulthood.

Methods: The data were derived from World Mental Health Survey Japan Second, a cross-sectional survey conducted among Japanese community residents between 2013 and 2015. We used the data of female respondents aged 20-75 years (N = 1171). Hazard ratio (HR) of the onset of major depression up to 40 years was calculated for an early-menarche group and a non-early-menarche group, respectively. Kaplan-Meier curve and log-rank statistics were used to examine the difference in failure. Cox proportional hazard models were administered for the association of major depression with early-menarche and early-life psychosocial factors.

Results: Risk for major depressive disorders were three to four times higher in an early-menarche group, and the differences in survival functions were significant (p < 0.001). HR of early menarche was 2.79 (95% CI = 1.29-6.02), and was slightly changed when childhood traumatic experience and socioeconomic conditions in young adulthood were added in the model (HR = 2.88, 95% CI = 1.30-6.38; HR = 3.19, 95% CI = 1.41-7.21).

Conclusion: Early menarche was significantly associated with increased risk for depression by the age of 40 years. Childhood trauma and socioeconomic hardship in early adulthood did not account for the association. Both physical and psychosocial risk factors in early life need to be addressed for preventing women's depression.

Keywords: Japan; child adversities; depression; menarche; women.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Kaplan–Meier curve for the occurrence of major depressive disorder from 10 to 40 years by the timing of menarche. Kaplan–Meier curves of an early menarche group (red) and the non‐early‐menarche group (blue) that show cumulative incidence rate of major depressive disorders between the age of 10 and 40 years.
See this image and copyright information in PMC

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References

    1. Vos T, Lim SS, Abbafati C, Abbas KM, Abbasi M, Abbasifard M, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990‐2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 2020;396(10258):1204–22. - PMC - PubMed
    1. Rehm J, Shield KD. Global Burden of Disease and the impact of mental and addictive disorders. Curr Psychiatry Rep. 2019;21(2):10. - PubMed
    1. Maughan B. Depression and psychological distress: a life course perspective. In: Kuh D, Hardy R editors. A life course approach to women's health. New York: Oxford; 2002. p. 161–76.
    1. Mendle J, Ryan RM, McKone KMP. Age at menarche, depression, and antisocial behavior in adulthood. Pediatrics. 2018;141(1): e20171703. - PMC - PubMed
    1. Copeland W, Shanahan L, Miller S, Costello EJ, Angold A, Maughan B. Outcomes of early pubertal timing in young women: a prospective population‐based study. Am J Psychiatry. 2010;167(10):1218–25. - PMC - PubMed