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Case Reports
. 2024 Apr 1;18(2):202-205.
doi: 10.18502/ijhoscr.v18i2.15378.

HHV-8 Linked to Kaposi's Sarcoma and Castleman's Disease in HIV-1-infected patient: Case Report and Review of the Literature

Aida Zaghdoudi  1 , Hajer Harrabi  2   3 , Hanene Tiouiri Benaissa  2   3
Affiliations
Case Reports

HHV-8 Linked to Kaposi's Sarcoma and Castleman's Disease in HIV-1-infected patient: Case Report and Review of the Literature

Aida Zaghdoudi et al. Int J Hematol Oncol Stem Cell Res. .

Abstract

Kaposi's sarcoma (KS) and multicentric Castleman's disease (MCD) are both linked to human herpesvirus-8 (HHV-8) infection which most commonly affects people living with human immunodeficiency virus (HIV). Herein, we describe the case of a 57-year-old patient who has been admitted for fever, night sweats, weight loss, and diffuse lymphadenopathy with abdominal pain. HIV status was confirmed by a positive Western blot test. His initial CD4 cell count was equal to 270 cells/µL. A histological study of a peripheral lymph node concluded that KS is associated with MCD. These two conditions found in the same patient highlight the malignant potential of HHV-8, particularly in the case of HIV-induced immunodeficiency.

Keywords: HIV; Human herpesvirus-8 (HHV-8); Kaposi’s sarcoma; Multicentric castleman’s disease (MCD).

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Conflict of interest statement

All authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Concentric rings of lymphocytes around germinal center « onion skinning » (arrow)
Figure 2
Figure 2
Proliferation of capillaries and small vessels in the germinal center and intrafollicular space (arrow)
Figure 3
Figure 3
Proliferation of spindle cells (arrow)
See this image and copyright information in PMC

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