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Review
. 2024 Aug;21(4):277-291.
doi: 10.1007/s11897-024-00671-z. Epub 2024 Jun 13.

The Role of Coagulation in Heart Failure: A Literature Review

Farhan Anjum  1 , Mahrukh Gilani  2 , Maryam Latif  1 , Aqsa Sattar  3 , Habiba Ashraf  2 , Saira Rafaqat  4
Affiliations
Review

The Role of Coagulation in Heart Failure: A Literature Review

Farhan Anjum et al. Curr Heart Fail Rep. 2024 Aug.

Abstract

Purpose of review: This article summarizes the role of coagulation factors in the pathophysiology of heart failure including D-dimer, fibrinogen and fibrin, prothrombin, p-selectin, tissue factor, tissue plasminogen activator, von Willebrand factor, β-thromboglobulin, Factor XI, tissue thromboplastin, plasminogen activator inhibitor-1 (PAI-1), thrombomodulin, soluble urokinase-type plasminogen activator receptor (suPAR) and stuart-prower factor.

Recent findings: The D-dimer, P-selectin, prothrombin, von Willebrand factor, tissue plasminogen activator, fibrinogen, suPAR, tissue factor, thrombomodulin and Factor XI play significant roles the pathophysiology of heart failure. However, no associations were found between β-thromboglobulin, tissue thromboplastin, PAI-1 and stuart-prower factor in the context of heart failure. Coagulation factors play significant role in the pathophysiology of heart failure. Consequently, the underlying pathophysiological mechanisms that explain changes in the cascade are closely related to the diagnostic, prognostic and therapeutic roles of coagulation cascade factors, which help physicians identify and treat heart failure.

Keywords: Coagulation factors; Heart failure; Pathophysiology.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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