Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 28:247:107798.
doi: 10.1016/j.toxicon.2024.107798. Epub 2024 Jun 12.

Platelet and red cell responses to three North American pit vipers

Samuel Francis  1 , Sanjay Khandelwal  2 , Richard Straight  3 , Luke Welton  3 , Pengfei Liang  4 , Huanghe Yang  4 , Charles J Gerardo  5 , Gowthami Arepally  2
Affiliations

Platelet and red cell responses to three North American pit vipers

Samuel Francis et al. Toxicon. .

Abstract

We investigated the hemotoxic effects of three North American pit vipers in healthy human donor blood. Using experiments focusing on platelet and red blood cell activity, we found differential effects of these venoms on these cellular components. Platelet aggregation was most induced by C. adamanteus. Platelet activation was highest with C. atrox. Red blood cells had calcium expression and erythrocyte formation most induced by C. adamanteus and A. piscivorus. These results demonstrate the complex interplay of individual cellular effects with clinical presentations seen in envenomings from these species.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Samuel Francis reports financial support was provided by BTG Specialty Pharmaceuticals. Luke Welton reports a relationship with BTG Specialty Pharmaceuticals that includes: employment. Richard Straight reports a relationship with BTG Specialty Pharmaceuticals that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

LinkOut - more resources