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. 2025 Jan;10(1):74-83.
doi: 10.1177/23800844241253250. Epub 2024 Jun 13.

High Anticholinergic Burden and Dental Caries: Findings from Northern Finland Birth Cohort 1966

A Tiisanoja  1   2   3 , V Anttonen  2   3 , A-M Syrjälä  2   3 , P Ylöstalo  2   3
Affiliations

High Anticholinergic Burden and Dental Caries: Findings from Northern Finland Birth Cohort 1966

A Tiisanoja et al. JDR Clin Trans Res. 2025 Jan.

Abstract

Introduction: Anticholinergic drugs propose a threat for oral health by causing dry mouth. The aim of this cross-sectional study was to investigate whether a high anticholinergic burden was associated with the presence of initial caries lesions, manifested caries lesions, dental fillings, or tooth loss among 46-y-old people.

Methods: The study population consisted of 1,906 participants from the Northern Finland Birth Cohort 1966 who underwent an oral health examination in 2012-2013. Socioeconomic and medical data were collected from questionnaires, medical records, and national registers. Nine previously published anticholinergic scales were combined and used to measure the high anticholinergic burden from the participants' medication data. Cariological status was determined according to the International Caries Detection and Assessment System, and the number of missing teeth (excluding third molars) was used as an indicator for tooth loss. The decayed, missing, and filled surfaces index was used to depict caries experience. Negative binominal regression models were used to estimate prevalence rate ratios (PRRs) and confidence intervals (CIs).

Results: Fourteen percent of the participants (n = 276) used at least 1 anticholinergic drug and about 3% had a high anticholinergic burden (n = 61). After adjusting for confounding factors, participants with a high anticholinergic burden had a higher likelihood of having manifested carious lesions needing restorative treatment (PRR, 1.60; CI, 1.11-2.29) and more missing teeth (PRR, 1.59; CI, 1.13-2.24) when compared to participants without any or with a lower anticholinergic burden.

Conclusions: High anticholinergic burden was associated with a present caries experience and with tooth loss among the general middle-aged population.

Knowledge transfer statement: The findings of this study suggest that middle-aged patients with a high anticholinergic burden may have a heightened risk of dental caries. These patients may benefit from targeted caries preventive regimes.

Keywords: adverse effects; anticholinergic agents; anticholinergics; cross sectional study.

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Conflict of interest statement

Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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