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. 2024 May 31;28(2):308.
doi: 10.3892/etm.2024.12597. eCollection 2024 Aug.

Association between lipid accumulation product index and chronic kidney disease: A systematic review and meta-analysis

Feixiang Wu  1 , Chenmin Cui  2 , Junping Wu  1 , Yunqing Wang  1
Affiliations

Association between lipid accumulation product index and chronic kidney disease: A systematic review and meta-analysis

Feixiang Wu et al. Exp Ther Med. .

Abstract

Diabetes mellitus and lipid metabolism disorders are increasingly recognized as key contributors to the development of chronic kidney disease (CKD). The lipid accumulation product (LAP) index, a novel marker of lipid accumulation, has potential implications for CKD risk assessment. The present meta-analysis aimed to assess the association between LAP index and CKD, with an emphasis on varying impacts in diabetic and non-diabetic populations. A comprehensive search for relevant publications was performed using PubMed/MEDLINE, Scopus, Cochrane Library, ScienceDirect and Google Scholar databases, and a meta-analysis of 17 studies was performed to investigate the relationship between LAP index and CKD. The random-effects inverse-variance model employing the DerSimonian-Laird estimator for τ² was utilized to calculate pooled odds ratios (ORs). Diagnostic accuracy was assessed using summary receiver operating characteristic (ROC) curves, with calculations of the area under the ROC curve (AUROC), sensitivity, specificity, likelihood ratios and diagnostic OR. The pooled OR for the association between higher quintiles or tertiles of LAP index and CKD was 1.098 (95% CI: 1.043-1.152), with substantial heterogeneity (I²=91.2%) and evidence of publication bias. Subgroup analysis revealed a stronger association in non-diabetic (OR=2.422, 95% CI: 1.802-3.042) compared with diabetic patients (OR=1.018, 95% CI: 0.993-1.043). The diagnostic accuracy of LAP index for CKD was moderate (AUROC=0.64), with sensitivity and specificity estimates of 0.58 and 0.63, respectively. In conclusion, in the present study, LAP index demonstrated a modest but significant association with CKD, particularly in non-diabetic patients. Despite its moderate diagnostic accuracy, the LAP index could serve as a valuable tool in CKD risk stratification, particularly when integrated with other clinical markers.

Keywords: chronic kidney disease; lipid accumulation product; meta-analysis.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Search strategy results. CKD, chronic kidney disease.
Figure 2
Figure 2
Forest plot showing the association between lipid accumulation product index and chronic kidney disease.
Figure 3
Figure 3
Subgroup analysis showing the association between lipid accumulation product index and chronic kidney disease based on DM status. DM, diabetes mellitus.
Figure 4
Figure 4
Subgroup analysis showing the association between lipid accumulation product index and chronic kidney disease based on the study design.
Figure 5
Figure 5
Diagnostic accuracy of lipid accumulation product index for predicting chronic kidney disease. sROC, summary receiver operating characteristic; AUC, area under the curve.
See this image and copyright information in PMC

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