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. 2024 Jun 8:16:725-735.
doi: 10.2147/NSS.S452665. eCollection 2024.

The Changed Nocturnal Sleep Structure and Higher Anxiety, Depression, and Fatigue in Patients with Narcolepsy Type 1

Jieyang Yu  1   2 , Yanan Zhang  1 , Lijia Cai  1 , Qingqing Sun  1 , Wanru Li  1 , Junfang Zhou  1 , Jianmin Liang  2 , Zan Wang  1
Affiliations

The Changed Nocturnal Sleep Structure and Higher Anxiety, Depression, and Fatigue in Patients with Narcolepsy Type 1

Jieyang Yu et al. Nat Sci Sleep. .

Abstract

Purpose: This study aimed to evaluate nocturnal sleep structure and anxiety, depression, and fatigue in patients with narcolepsy type 1 (NT1).

Methods: Thirty NT1 patients and thirty-five healthy controls were enrolled and evaluated using the Epworth sleepiness scale (ESS), Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, Fatigue Severity Scale (FSS), polysomnography, multiple sleep latency test, and brain function state monitoring. Statistical analyses were performed using SPSS Statistics for Windows, version 23.0. Benjamini-Hochberg correction was performed to control the false discovery rate.

Results: Apart from typical clinical manifestations, patients with NT1 are prone to comorbidities such as nocturnal sleep disorders, anxiety, depression, and fatigue. Compared with the control group, patients with NT1 exhibited abnormal sleep structure, including increased total sleep time (P adj=0.007), decreased sleep efficiency (P adj=0.002), shortening of sleep onset latency (P adj<0.001), elevated wake after sleep onset (P adj=0.002), increased N1% (P adj=0.006), and reduced N2%, N3%, and REM% (P adj=0.007, P adj<0.001, P adj=0.013). Thirty-seven percent of patients had moderate to severe obstructive sleep apnea-hypopnea syndrome. And sixty percent of patients were complicated with REM sleep without atonia. Patients with NT1 displayed increased anxiety propensity (P adj<0.001), and increased brain fatigue (P adj=0.020) in brain function state monitoring. FSS scores were positively correlated with brain fatigue (P adj<0.001) and mean sleep latency was inversely correlated with FSS scores and brain fatigue (P adj=0.013, P adj=0.029). Additionally, ESS scores and brain fatigue decreased after 3 months of therapy (P=0.012, P=0.030).

Conclusion: NT1 patients had abnormal nocturnal sleep structures, who showed increased anxiety, depression, and fatigue. Excessive daytime sleepiness and fatigue improved after 3 months of treatment with methylphenidate hydrochloride prolonged-release tablets in combination with venlafaxine.

Keywords: anxiety; depression; excessive daytime sleepiness; fatigue; narcolepsy; sleep structure.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Comparison of anxiety propensity and brain fatigue between patients with NT1 and the control group (Ranks plot). (a) Comparison of anxiety propensity between NT1 patients and the control group; (b) Comparison of brain fatigue between NT1 patients and the control group.
Figure 2
Figure 2
Correlation between FSS scores, mean sleep latency, and brain fatigue in patients with NT1. (a) Correlation between FSS scores and brain fatigue in patients with NT1; (b) Correlation between mean sleep latency and brain fatigue in patients with NT1; (c) Correlation between FSS scores and mean sleep latency in patients with NT1.
Figure 3
Figure 3
Changes in ESS scores and brain fatigue before and after drug treatment. (a) Changes in ESS scores before and after treatment; (b) Changes in brain fatigue before and after treatment.
See this image and copyright information in PMC

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