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. 2024 Dec;46(2):2364762.
doi: 10.1080/0886022X.2024.2364762. Epub 2024 Jun 14.

Exploring the relationship between creatine supplementation and renal function: insights from Mendelian randomization analysis

Bing Zhou  1 , Minping Hong  1 , Liqin Jin  2 , Keng Ling  2
Affiliations

Exploring the relationship between creatine supplementation and renal function: insights from Mendelian randomization analysis

Bing Zhou et al. Ren Fail. 2024 Dec.

Abstract

Background: Creatine supplementation is ubiquitously consumed by fitness enthusiasts due to its perceived advantages in enhancing athletic performance. Although there is an increasing concern within this demographic regarding its possible impact on renal function, there is still a lack of rigorous scientific investigations into this alleged association.

Methods: Data were collected through an online survey on the participants' demographics, creatine usage and concerns related to renal function. The reliability and validity of the survey were assessed using SPSS software. A total of 1129 participants responded to the survey, and chi-square tests were utilized for data analysis. To explore the potential association between creatine levels (as the exposure) and renal function (as the outcome), we utilized open-access genetic databases, and Mendelian randomization (MR) techniques were used to confirm this correlation.

Results: Chi-square analysis revealed no significant association between creatine usage and renal function among the participants. Our MR analysis further supported this finding, demonstrating no significant association between creatine levels and six indicators assessing renal function (IVW, all with p values exceeding 0.05). Similar p values were consistently observed across other MR methods, confirming the absence of a statistical correlation.

Conclusions: This MR study offers compelling evidence indicating that creatine levels are not statistically associated with renal function, suggesting the potential to alleviate concerns within the fitness community and emphasizing the significance of evidence-based decision-making when considering nutritional supplementation.

Keywords: Creatine supplementation; Mendelian randomization; fitness enthusiasts; renal function.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
Forest Plots showed the causal associations between creatine levels and six indicators evaluating renal function traits. IVW: inverse variance weighting; CI: confidence interval.
See this image and copyright information in PMC

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