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. 2024:35:435-451.
doi: 10.1007/978-3-031-45493-6_21.

Depression, Cancer, Inflammation, and Endogenous Opioids: Pathogenic Relationships and Therapeutic Options

Jennifer Hancock  1 , Cristian Sirbu  2 , Patrick L Kerr  3
Affiliations

Depression, Cancer, Inflammation, and Endogenous Opioids: Pathogenic Relationships and Therapeutic Options

Jennifer Hancock et al. Adv Neurobiol. 2024.

Abstract

Endogenous opioids and their associated receptors form a system that maintains survival by positively reinforcing behaviors that are vital to life. Cancer and cancer treatment side effects capitalize on this system pathogenically, leading to maladaptive biological responses (e.g., inflammation), as well as cognitive and emotional consequences, most notably depression. Psychologists who treat people with cancer frequently find depression to be a primary target for intervention. However, in people with cancer, the etiology of depression is unique and complex. This complexity necessitates that psycho-oncologists have a fundamental working knowledge of the biological substrates that underlie depression/cancer comorbidity. Building on other chapters in this volume pertaining to cancer and endogenous opioids, this chapter focuses on the clinical applications of basic scientific findings.

Keywords: Cancer; Endogenous opioids; Psycho-oncology.

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References

    1. Ahmad, M. H., Rizvi, M. A., Fatima, M., & Mondal, A. C. (2021). Pathophysiological implications of neuroinflammation mediated HPA axis dysregulation in the prognosis of cancer and depression. Molecular and Cellular Endocrinology, 520, 111093. - PubMed - DOI
    1. Al Maqbali, M., Al Sinani, M., Al Naamani, Z., & Al Badi, K. (2021). Prevalence of fatigue in patients with cancer: A systematic review and meta-analysis. Journal of Pain and Symptom Management, 61(1), 167–189. - PubMed - DOI
    1. Ancoli-Israel, S., Moore, P. J., & Jones, V. (2001). The relationship between fatigue and sleep in cancer patients: A review. European Journal of Cancer Care, 10(4), 245–255. - PubMed - PMC - DOI
    1. Antoni, M. H., & Dhabhar, F. S. (2019). The impact of psychosocial stress and stress management on immune responses in patients with cancer. Cancer, 125(9), 1417–1431. - PubMed - DOI
    1. Antoni, M. H., Lechner, S., Diaz, A., Vargas, S., Holley, H., Phillips, K., et al. (2009). Cognitive behavioral stress management effects on psychosocial and physiological adaptation in women undergoing treatment for breast cancer. Brain, Behavior, and Immunity, 23(5), 580–591. - PubMed - DOI

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