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Case Reports
. 2024 Sep-Oct;99(5):778-780.
doi: 10.1016/j.abd.2023.08.017. Epub 2024 Jun 13.

Bullous pemphigoid successfully treated with dupilumab

Daniela de Abreu E Silva Martinez  1 , Amanda de Freitas Sampaio Periquito  2 , Graciela Galva Roa  2 , João Pedro Lupi  3 , Curt Mafra Treu  2 , Omar Lupi  4
Affiliations
Case Reports

Bullous pemphigoid successfully treated with dupilumab

Daniela de Abreu E Silva Martinez et al. An Bras Dermatol. 2024 Sep-Oct.
No abstract available

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Figures

Figure 1
Figure 1
Isolated tight blisters can be seen on the right thigh.
Figure 2
Figure 2
Erosions on the trunk and buttocks.
Figure 3
Figure 3
Hematoxylin & eosin, 100x. Revealing subepidermal blister formation with eosinophilic infiltrate.
Figure 4
Figure 4
Lesions resolved with post-inflammatory hyperpigmantation.
See this image and copyright information in PMC

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References

    1. Russo R., Capurro N., Cozzani E., Parodi A. Use of dupilumab in bullous pemphigoid: where are we now? J Clin Med. 2022;11:3367. - PMC - PubMed
    1. Zhang Y., Xu Q., Chen L., Chen J., Zhang J., Zou Y., Gong T., Ji C. Efficacy and safety of dupilumab in moderate-to-severe bullous pemphigoid. Front Immunol. 2021;12 - PMC - PubMed
    1. Zhang L., Chen Z., Wang L., Luo X. Bullous pemphigoid: the role of type 2 inflammation in its pathogenesis and the prospect of targeted therapy. Front Immunol. 2023;14 - PMC - PubMed
    1. Zhou A.E., Shao K., Ferenczi K., Adalsteinsson J.A. Recalcitrant bullous pemphigoid responsive to dupilumab in an adolescent patient. JAAD Case Rep. 2022;29:149–151. - PMC - PubMed
    1. Santi C.G., Gripp A.C., Roselino A.M., Mello D.S., Gordilho J.O., Marsillac P.F., et al. Consensus on the treatment of autoimmune bullous dermatoses: bullous pemphigoid, mucous membrane pemphigoid and epidermolysis bullosa acquisita - Brazilian Society of Dermatology. An Bras Dermatol. 2019;94:33–47. - PMC - PubMed

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