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Meta-Analysis
. 2024 Jun 14;19(1):332.
doi: 10.1186/s13019-024-02781-0.

Efficacy of autologous blood patch injection for pneumothorax rate after CT-guided percutaneous transthoracic lung biopsy: a systematic review and meta-analysis

Xin Chen #  1 , Yungui Bian #  2 , Hai Li  3 , Shurong Li  4 , Zhaowen Shi  1 , Yunping Zhao  5 , Haibin Li  5 , Yanlong Yang  6
Affiliations
Meta-Analysis

Efficacy of autologous blood patch injection for pneumothorax rate after CT-guided percutaneous transthoracic lung biopsy: a systematic review and meta-analysis

Xin Chen et al. J Cardiothorac Surg. .

Abstract

Background: Pneumothorax is the most frequent complication after CT-guided percutaneous transthoracic lung biopsy (CT-PTLB). Many studies reported that injection of autologous blood patch (ABP) during biopsy needle withdrawal could reduce the pneumothorax and chest tube insertion rate after CT-PTLB, but the result is debatable. The aim of this systematic review and meta-analysis is to synthesize evidence regarding the efficacy of ABP procedure in patients receiving CT-PTLB.

Methods: Eligible studies were searched in Pubmed, Embase and Web of Science databases. The inclusion criteria were studies that assessed the relationship between ABP and the pneumothorax and/or chest tube insertion rate after CT-PTLB. Subgroup analyses according to study type, emphysema status and ABP technique applied were also conducted. Odds ratio (OR) with 95% confidence interval (CI) were calculated to examine the risk association.

Results: A total of 10 studies including 3874 patients were qualified for analysis. Our analysis suggested that ABP reduced the pneumothorax (incidence: 20.0% vs. 27.9%, OR = 0.67, 95% CI = 0.48-0.66, P < 0.001) and chest tube insertion rate (incidence: 4.0% vs. 8.0%, OR = 0.47, 95% CI = 0.34-0.65, P < 0.001) after CT-PTLB. Subgroup analysis according to study type (RCT or retrospective study), emphysema status (with or without emphysema), and ABP technique applied (clotted or non-clotted ABP) were also performed and we found ABP reduced the pneumothorax and chest tube insertion rate in all subgroups.

Conclusions: Our study indicated that the use of ABP was effective technique in reducing the pneumothorax and chest tube insertion rate after CT-PTLB.

Keywords: Autologous blood Patch; CT-guided percutaneous transthoracic lung biopsy; Pneumothorax.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flow diagram of studies selection procedure
Fig. 2
Fig. 2
Forest plot of the association between ABP use and pneumothorax rate after CT-PTLB
Fig. 3
Fig. 3
Forest plot of the association between ABP use and pneumothorax rate in patients with emphysema (A) and without emphysema (B) after CT-PTLB
Fig. 4
Fig. 4
Forest plot of the association between ABP use and chest tube insertion rate after CT-PTLB.
Fig. 5
Fig. 5
Sensitivity analyses omitting one study each time on the influence of ABP use and pneumothorax rate (A) and chest tube insertion rate (B) after CT-PTLB
Fig. 6
Fig. 6
The funnel plot of the meta-analysis of the impact of ABP on pneumothorax (A) and chest tube insertion rate (B) in patients after CT-PTLB.
See this image and copyright information in PMC

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