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. 2024 Sep;110(1):116327.
doi: 10.1016/j.diagmicrobio.2024.116327. Epub 2024 May 5.

Culture-independent Multilocus sequence typing screening for Haemophilus influenzae cross-infection in non-cystic fibrosis bronchiectasis

Catherine R Wilson  1 , Philip J Mitchelmore  2 , Nicholas Withers  2 , Alan R Brown  2
Affiliations

Culture-independent Multilocus sequence typing screening for Haemophilus influenzae cross-infection in non-cystic fibrosis bronchiectasis

Catherine R Wilson et al. Diagn Microbiol Infect Dis. 2024 Sep.

Abstract

Whether cross-infection of respiratory pathogens between patients with non-cystic fibrosis bronchiectasis occurs is debated. Investigation with traditional microbiological culture risks simplifying the lung microbiome. We demonstrate the use of culture-independent Multilocus sequence typing to screen for Haemophilus influenzae strain types in a cohort of twenty-eight patients with non-cystic fibrosis bronchiectasis.

Keywords: Culture-independent MLST; Haemophilus influenzae; Multi-locus sequence typing; cross-infection; non-cystic fibrosis bronchiectasis.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper). CW received salary support from the Wellcome Trust ISSF grant.