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Review
. 2025 Feb;480(2):733-745.
doi: 10.1007/s11010-024-05048-3. Epub 2024 Jun 16.

Role of natural products in cardiovascular disease

Qi Dong  1 , Gaoying Dai  1 , Nanhu Quan  2 , Qian Tong  3
Affiliations
Review

Role of natural products in cardiovascular disease

Qi Dong et al. Mol Cell Biochem. 2025 Feb.

Abstract

As the world's aging population increases, cardiovascular diseases (CVDs) associated with aging deserve increasing attention. CVD in association with age is considered a major cause of morbidity and mortality worldwide. In this review, we provide an overview of the key molecular pathways, cellular processes such as autophagy, oxidative stress, inflammatory responses, myocardial remodeling and ischemia-refocused injury that accompany CVD as well as the natural products of targeting these mechanisms and some of the dietary habits that have been studied in cardiovascular-related diseases. The potential preventive and therapeutic avenues resulting from these dietary habits and natural products related to animal models and clinical studies can help us to better understand the processes involved in cardiovascular diseases and provide recommendations to reduce the cardiovascular burden associated with aging heart.

Keywords: CVD; Cardiovascular protection; Natural products.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

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