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. 2024 Jun 17;24(1):260.
doi: 10.1186/s12886-024-03481-y.

Peripapillary RNFL cross-sectional area and its association with other parameters in a Chinese population

Yan Yanni  1 , Wang Qian  1 , Wei Wenbin  2
Affiliations

Peripapillary RNFL cross-sectional area and its association with other parameters in a Chinese population

Yan Yanni et al. BMC Ophthalmol. .

Abstract

Background: Quantitative analysis of retinal nerve fibers is important for the diagnosis and treatment of optic nerve diseases. Peripapillary retinal nerve fiber layer (RNFL) cross-sectional area may give a more accurate quantitative assessment of retinal nerve fibers than RNFL thickness but there have been no previous reports of the peripapillary RNFL cross-sectional area or other parameters. The purpose of the current study was to determine peripapillary RNFL cross-sectional area and its association with other factors in an adult Chinese population.

Methods: RNFL cross-sectional area was measured during peripapillary circular optical coherence tomography (OCT) scan with a diameter of 12° centered on the optic disc. Correlation between RNFL cross-sectional area and other parameters was evaluated by linear regression analysis in a cross-sectional study of an adult Chinese population.

Results: A total of 2404 eyes from 2404 subjects were examined. Multivariate linear regression analysis showed that larger RNFL cross-sectional area correlated with younger age (p < 0.001), female gender (p = 0.001), no history of diabetes (p = 0.012) and larger optic disc area (p < 0.001).

Conclusions: Peripapillary RNFL cross-sectional area is correlated positively with optic disc area, suggesting that eyes with larger optic discs have thicker RNFL. Further studies are needed to confirm whether this correlation is due to differences in the numbers of retinal nerve fibers or other factors.

Keywords: Ocular magnification; Optic disc area; Peripapillary RNFL cross-sectional area.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Method of peripapillary RNFL cross-sectional area measurement. Figure A: green line indicates peripapillary circular scanning path and arrow indicates a anticlockwise scanning direction for the left eye. The scanning circle diameter was automatically calculated by Heidelberg Eye Explorer software. Figure B: cross-section of the retina under the scanning path of Figure A. The red line represents the internal limiting membrane and the green line represents the interface between the retinal nerve fiber layer and the ganglion cell layer. The area between them is the cross-sectional area of the nerve fiber layer
See this image and copyright information in PMC

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