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Review
. 2024 Sep;25(9):e13791.
doi: 10.1111/obr.13791. Epub 2024 Jun 16.

Tissue-specific roles of mitochondrial unfolded protein response during obesity

Fernanda S Carneiro  1 , Carlos K Katashima  1 , Joshua D Dodge  2 , Dennys E Cintra  3 , José Rodrigo Pauli  1   4 , Adelino S R Da Silva  5 , Eduardo R Ropelle  1   4
Affiliations
Review

Tissue-specific roles of mitochondrial unfolded protein response during obesity

Fernanda S Carneiro et al. Obes Rev. 2024 Sep.

Abstract

Obesity is a worldwide multifactorial disease caused by an imbalance in energy metabolism, increasing adiposity, weight gain, and promoting related diseases such as diabetes, cardiovascular diseases, neurodegeneration, and cancer. Recent findings have reported that metabolic stress related to obesity induces a mitochondrial stress response called mitochondrial unfolded protein response (UPRmt), a quality control pathway that occurs in a nuclear DNA-mitochondria crosstalk, causing transduction of chaperones and proteases under stress conditions. The duality of UPRmt signaling, with both beneficial and detrimental effects, acts in different contexts depending on the tissue, cell type, and physiological states, affecting the mitochondrial function and efficiency and the metabolism homeostasis during obesity, which remains not fully clarified. Therefore, this review discusses the most recent findings regarding UPRmt signaling during obesity, bringing an overview of UPRmt across different metabolic tissues.

Keywords: metabolism; mitochondria; mitochondrial unfolded protein response; obesity.

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References

REFERENCES

    1. WHO. Obesity and overweight. 2021. Accessed March 2, 2023. https://www.who.int/en/news‐room/fact‐sheets/detail/obesity‐and‐overweight
    1. Saltiel AR, Olefsky JM. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017;127(1):1‐4. doi:10.1172/JCI92035
    1. Curley S, Gall J, Byrne R, Yvan‐Charvet L, McGillicuddy FC. Metabolic inflammation in obesity‐at the crossroads between fatty acid and cholesterol metabolism. Mol Nutr Food Res. 2021;65(1):e1900482. doi:10.1002/MNFR.201900482
    1. Pakos‐Zebrucka K, Koryga I, Mnich K, Ljujic M, Samali A, Gorman AM. The integrated stress response. EMBO Rep. 2016;17(10):1374‐1395. doi:10.15252/EMBR.201642195
    1. Anderson NS, Haynes CM. Folding the mitochondrial UPR into the integrated stress response. Trends Cell Biol. 2020;30(6):428‐439. doi:10.1016/j.tcb.2020.03.001

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