[Antitumor effect of JM-8 (a cisplatin analogue) on testicular cancer cells in vitro and in vivo]

Abstract

Using transplantable testicular tumor lines serially passaged in nude mice, the antitumor effect of JM-8, an analogue compound of cisplatin, was evaluated by clonogenic assay and in nude mice. JM-8 exhibited compatible tumor growth inhibition to that of 8 to 10 times the concentration of cisplatin both in vitro and in vivo. In addition, JM-8 had less toxicity than cisplatin in vivo. However, when JM-8 was adopted for treatment of regrowing tumors after repeated manipulations with cisplatin, it exerted less growth inhibition than cisplatin. Apart from this effect, it was considered that JM-8 could be substituted for cisplatin in clinical use.