Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 18;37(8):715-721.
doi: 10.1515/jpem-2024-0124. Print 2024 Aug 27.

Retrospective evaluation of patients diagnosed with central precocious puberty who reached the final height

Kadri Yaman  1 , Edip Unal  1 , Aslı Beştaş  1 , Amine Aktar Karakaya  1 , Nurcan Beyazıt  1 , Barış Kolbaşı  1
Affiliations

Retrospective evaluation of patients diagnosed with central precocious puberty who reached the final height

Kadri Yaman et al. J Pediatr Endocrinol Metab. .

Abstract

Objectives: Central precocious puberty (CPP) is the onset of puberty before the age of 8 in girls and 9 in boys. The primary goal of CPP treatment is control and arrest of puberty development. In this study, it was aimed to determine the factors associated with final height in patients who received gonadotropin-releasing hormone analogs (GnRHa) treatment and reached their final height.

Methods: From the medical records of the patients, age on admission, bone age (BA), weight-standard deviation score (SDS), height-SDS, BMI-SDS, target height-SDS, basal LH, FSH, E2, age at menarche, and pelvic USG findings were obtained.

Results: The mean age on admission of the 67 female patients was 7.5 ± 0.60 years. On admission, 4.5 % of the patients were obese and 19.4 % were overweight. There was no difference between BMI-SDS at admission and after treatment. The mean age at menarche was 11.57 ± 0.78 years. About 58.2 % of the patients reached the target height, 35.8 % exceeded the target height, and 6 % were below the target height. The mean height-SDS and predicted adult height (PAH) on admission were better in patients who exceeded the target height. It was determined that target height-SDS had a positive effect on delta height-SDS, while BA/CA ratio had a negative effect.

Conclusions: It was found that GnRHa treatment did not have a negative effect on BMI-SDS. It was shown that 94 % of the patients who received GnRHa treatment reached the target height, and in fact, 35.8 % exceeded the target height. A greater final height may be associated with good height-SDS and PAH values on admission.

Keywords: central precocious puberty; final height; gonadotropin-releasing hormone analog treatment.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Cheuiche, AV, da Silveira, LG, de Paula, LCP, Lucena, IRS, Silveiro, SP. Diagnosis and management of precocious sexual maturation: an updated review. Eur J Pediatr 2021;180:3073–87. https://doi.org/10.1007/s00431-021-04022-1 . - DOI
    1. Neyzi, O, Günöz, H, Furman, A, Bundak, R, Gökçay, G, Darendeliler, F, et al.. Reference values of body weight, height, head circumference and body mass index in Turkish children. J Child Health Dis 2008;51:1–14.
    1. de Onis, M, Onyango, AW, Borghi, E, Siyam, A, Nishida, C, Siekmann, J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 2007;85:660–7. https://doi.org/10.2471/blt.07.043497 . - DOI
    1. Greulich, W, Pyle, S. Radiographic atlas of skeletal development of the hand and wrist . Stanford, CA: Stanford University Press; 1959.
    1. Bar, A, Linder, B, Sobel, EH, Saenger, P, DiMartino-Nardi, J. Bayley-Pinnea method of height prediction in girls with central precocious puberty: correlation with adult height. J Pediatr 1995;126:955–8. https://doi.org/10.1016/s0022-3476(95)70221-0 . - DOI

Substances

LinkOut - more resources