Single-dose amoxycillin in the treatment of bacteriuria in pregnancy and the puerperium--a controlled clinical trial

Abstract

Ninety obstetric patients with significant bacteriuria were treated randomly with either a single dose of 3 g amoxycillin or with a conventional course of ampicillin over 7 days. Treatment groups were comparable in terms of age, gravidity and socioeconomic status, and the outcome of pregnancy in the two groups did not differ significantly. Cure rates, assessed at 1 week and 6 weeks after treatment, were not significantly different: 88% for single-dose treatment and 84% for conventional treatment. It is concluded that a single dose of 3 g amoxycillin is a safe, effective and acceptable treatment for bacteriuria in pregnancy and the puerperium.