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Case Reports
. 2024 Jun 14;12(6):e8803.
doi: 10.1002/ccr3.8803. eCollection 2024 Jun.

Allergy to Theobroma Cacao

Ana Nin Valencia  1   2 , Lorena Soto Retes  1   2 , Borja Bartolomé-Zavala  3 , Gustavo Perdomo Gutiérrez  1   2 , Teresa Bigorra  1   2
Affiliations
Case Reports

Allergy to Theobroma Cacao

Ana Nin Valencia et al. Clin Case Rep. .

Erratum in

Abstract

We present the case of a patient with antecedent of tree nuts allergy who developed an anaphylactic reaction after ingesting a piece chocolate. An allergy study detected sensitization to cocoa in skin tests as well as cross-reactivity with tree nuts in the SDS-PAGE immunoblotting-inhibition.

Keywords: allergy; cocoa; cross reactivity; tree nuts.

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Prick test results. Skin test results. From up to down (H): histamine positive control; (S): saline negative control; (1) Almond extract: positive, (2) cocoa extract: positive, and (3) walnut extract: positive.
FIGURE 2
FIGURE 2
(I) SDS‐PAGE IgE‐Immunoblotting. (A) Raw cocoa bean (B) Raw cocoa bean extract (C) Cocoa powder (D) Cocoa powder extract (E) Walnut extract (F) Hazelnut extract. Lane P: Patient serum Lane C: Control serum (pool of sera from non‐atopic subject) Lane M: Molecular mass marker. (II) SDS‐PAGE Immunoblotting‐inhibition. Cocoa powder extract in solid phase. Lane C: Control serum, Lane 1–4: Patient serum pre‐incubated with cocoa extract (lane 1), with walnut extract (lane 2), with almond extract (lane 3), with lamb extract (lane 4).
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