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Case Reports
. 2024 Jun 14;12(6):e8803.
doi: 10.1002/ccr3.8803. eCollection 2024 Jun.

Allergy to Theobroma Cacao

Ana Nin Valencia  1   2 , Lorena Soto Retes  1   2 , Borja Bartolomé-Zavala  3 , Gustavo Perdomo Gutiérrez  1   2 , Teresa Bigorra  1   2
Affiliations
Case Reports

Allergy to Theobroma Cacao

Ana Nin Valencia et al. Clin Case Rep. .

Erratum in

Abstract

We present the case of a patient with antecedent of tree nuts allergy who developed an anaphylactic reaction after ingesting a piece chocolate. An allergy study detected sensitization to cocoa in skin tests as well as cross-reactivity with tree nuts in the SDS-PAGE immunoblotting-inhibition.

Keywords: allergy; cocoa; cross reactivity; tree nuts.

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Prick test results. Skin test results. From up to down (H): histamine positive control; (S): saline negative control; (1) Almond extract: positive, (2) cocoa extract: positive, and (3) walnut extract: positive.
FIGURE 2
FIGURE 2
(I) SDS‐PAGE IgE‐Immunoblotting. (A) Raw cocoa bean (B) Raw cocoa bean extract (C) Cocoa powder (D) Cocoa powder extract (E) Walnut extract (F) Hazelnut extract. Lane P: Patient serum Lane C: Control serum (pool of sera from non‐atopic subject) Lane M: Molecular mass marker. (II) SDS‐PAGE Immunoblotting‐inhibition. Cocoa powder extract in solid phase. Lane C: Control serum, Lane 1–4: Patient serum pre‐incubated with cocoa extract (lane 1), with walnut extract (lane 2), with almond extract (lane 3), with lamb extract (lane 4).
See this image and copyright information in PMC

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