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. 2024 May 17:19:Doc27.
doi: 10.3205/dgkh000482. eCollection 2024.

Incidence of side effects of antituberculosis drugs and their related factors in northern Iran: a retrospective cohort study

Motahareh Kheradmand  1 , Mahdi Afshari  2 , Mohsen Aarabi  3 , Siavosh Abedi  4 , Mohammadreza Parsaee  5 , Asghar Nezammahalleh  5 , Mahmood Moosazadeh  6
Affiliations

Incidence of side effects of antituberculosis drugs and their related factors in northern Iran: a retrospective cohort study

Motahareh Kheradmand et al. GMS Hyg Infect Control. .

Abstract
in English, German

Background: Antituberculosis drugs may cause mild, moderate or severe adverse drug reactions (ADR) leading to poor compliance. Description of the pattern of ADR and their related factors can help tuberculosis (TB) control program as part of the WHO programs. This study aims to investigate the incidence of ADR and associated factors among TB patients in northern Iran.

Methods: This is a retrospective cohort study. The required information, including year of diagnosis, age, gender, residence area, nationality, HIV co-morbidity, history of anti TB treatment and ADR, was obtained from the Deputy of Health, Mazandaran University of Medical Sciences, Iran. All data were analyzed using SPSS version 21 software.

Results: Out of 3903 TB patients, 136 (3.5%) experienced major ADR. The incidence of ADR for men and women as well as for those with and without previous treatment history were 3.9% vs. 3.3% and 5.3% vs. 3.4%, respectively (p>0.05). Multiple logistic regression models showed a higher chance of ADR among those aged over 59 compared with those aged under 29 (OR=2.63, 95% confidence interval: 1.54-4.49).

Conclusions: Age over 59 can be considered a risk factor for ADR with anti-TB drug administration.

Zielsetzung: Antituberkulostatika (AT) können leichte, mittelschwere oder schwere unerwünschte Arzneimittelwirkungen (UAW) verursachen, die zu einer schlechten Compliance führen. Die Beschreibung des Musters von UAW und der damit zusammenhängenden Faktoren kann dem Tuberkulose(TB)-Kontrollprogramm helfen. Ziel der Studie ist es, die Häufigkeit von UAW und die damit zusammenhängenden Faktoren bei TB-Patienten im Norden des Irans zu untersuchen.

Methode: Es handelt es sich um eine retrospektive Kohortenstudie. Die erforderlichen Informationen einschließlich Diagnosejahr, Alter, Geschlecht, Wohnort, Staatsangehörigkeit, HIV-Komorbidität, Vorgeschichte der TB-Behandlung und UAW, wurden vom stellvertretenden Gesundheitsamt der Mazandaran Universität für Medical Sciences, Iran, bereitgestellt und mit der Software SPSS Version 21 ausgewertet.

Ergebnisse: Von 3903 TB-Patienten traten bei 136 (3,5%) schwerwiegende UAW auf. Die Häufigkeit von UAW bei Männern bzw. Frauen betrug bei vorheriger Behandlung 3,9% bzw. 3,3%, ohne vorherige Behandlung 5,3% bzw. 3,4% (p>0,05). Multiple logistische Regressionsmodelle ergaben, dass die Wahrscheinlichkeit einer UAW bei über 59-Jährigen höher war als bei unter 29-Jährigen (OR=2,63, 95 % Konfidenzintervall: 1,54–4,49).

Schlussfolgerung: Ein Alter über 59 Jahren kann als Risikofaktor für UAW gegen Antituberkulostatika angesehen werden.

Keywords: adverse drug reaction; antituberculosis drugs; risk factor.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Table 1
Table 1. Factors related to ADR based on univariate and multivariate analysis
See this image and copyright information in PMC

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