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Review
. 2024:1441:853-865.
doi: 10.1007/978-3-031-44087-8_52.

Molecular Pathways and Animal Models of Truncus Arteriosus

Eleanor Gill  1 , Simon D Bamforth  2
Affiliations
Review

Molecular Pathways and Animal Models of Truncus Arteriosus

Eleanor Gill et al. Adv Exp Med Biol. 2024.

Abstract

In normal cardiovascular development in birds and mammals, the outflow tract of the heart is divided into two distinct channels to separate the oxygenated systemic blood flow from the deoxygenated pulmonary circulation. When the process of outflow tract septation fails, a single common outflow vessel persists resulting in a serious clinical condition known as persistent truncus arteriosus or common arterial trunk. In this chapter, we will review molecular pathways and the cells that are known to play a role in the formation and development of the outflow tract and how genetic manipulation of these pathways in animal models can result in common arterial trunk.

Keywords: Common arterial trunk; Congenital heart defects; Extracellular matrix; FGF; Genetics; Model organisms; Neural crest cells; Persistent truncus arteriosus; TBX1; TGFβTransforming growth factors (TGFs)TGFß.

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