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Review
. 2025 Feb;480(2):747-757.
doi: 10.1007/s11010-024-05049-2. Epub 2024 Jun 17.

Functional transformation of macrophage mitochondria in cardiovascular diseases

Jing Wei  1 , Ming-Yu Peng  2 , Hong-Xiang Lu  3   4
Affiliations
Review

Functional transformation of macrophage mitochondria in cardiovascular diseases

Jing Wei et al. Mol Cell Biochem. 2025 Feb.

Abstract

Mitochondria are pivotal in the modulation of macrophage activation, differentiation, and survival. Furthermore, macrophages are instrumental in the onset and progression of cardiovascular diseases. Hence, it is imperative to investigate the role of mitochondria within macrophages in the context of cardiovascular disease. In this review, we provide an updated description of the origin and classification of cardiac macrophages and also focused on the relationship between macrophages and mitochondria in cardiovascular diseases with respect to (1) proinflammatory or anti-inflammatory macrophages, (2) macrophage apoptosis, (3) macrophage pyroptosis, and (4) macrophage efferocytosis. Clarifying the relationship between mitochondria and macrophages can aid the exploration of novel therapeutic strategies for cardiovascular disease.

Keywords: Apoptosis; Cardiovascular disease; Efferocytosis; Macrophages; Mitochondria; Pyroptosis.

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Conflict of interest statement

Declarations. Competing interests: The authors declare that they have no competing interests. Ethical approval: No ethics approval was required for this review that did not involve patients or patient data. Consent for publication: We have obtained consents to publish this paper from all the participants of this study.

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