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. 1985;31(3):200-3.
doi: 10.1159/000238336.

Inhibitory activity of cefpiramide on beta-lactamase

K P Fu, S McCloud, F J Gregory, P P Hung

Inhibitory activity of cefpiramide on beta-lactamase

K P Fu et al. Chemotherapy. 1985.

Abstract

The beta-lactamase stability and inhibitory activity of cefpiramide were investigated. Cefpiramide was found to be stable to hydrolysis and inhibited beta-lactamase produced by Citrobacter freundii, Enterobacter cloacae, Morganella morganii, and Escherichia coli. Kinetic studies showed that cefpiramide is a competitive inhibitor of cephaloridine hydrolysis by E. cloacae beta-lactamase.

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