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. 2024 Jul:213:111750.
doi: 10.1016/j.diabres.2024.111750. Epub 2024 Jun 15.

Incidence of type 1 diabetes in Sardinian children aged 0-14 years has almost doubled in the last twenty years. On top of the world

Carlo Ripoli  1 , Maria R Ricciardi  2 , Maria R Angelo  2 , Gianfranco Meloni  3 , Antonello Pippia  4 , Grazia Pintori  5 , Gavina Piredda  6 , Maria M Orrù  7 , Augusto Ogana  7 , Rosella Maccioni  8 , Maria P Scanu  8 , Giovanna L Conti  9 , Antonella Correddu  10 , Valeria Corona  11 , Pasquale Bulciolu  12 , Laura Concas  13 , Osama Aljamal  13
Affiliations

Incidence of type 1 diabetes in Sardinian children aged 0-14 years has almost doubled in the last twenty years. On top of the world

Carlo Ripoli et al. Diabetes Res Clin Pract. 2024 Jul.

Abstract

Aims: The primary objectives were to investigate the incidence rate (IR) of type 1 diabetes (T1D) in Sardinian children aged 0-14 years in 2019-2022 and to examine the temporal trend from 1989-1999.

Methods: Data from new-onset T1D patients aged 0-14 years who were residents of Sardinia were collected from all pediatric diabetology clinics. The overall, sex- and age specific (groups 0-4, 5-9, and 10-14 years), and calendar year IRs were calculated. The standardized IR (SIR) was also calculated using the direct method. Poisson regression was used to estimate the temporal trend in the SIRs from 1989-1999 to 2019-2022.

Results: In 2019-2022, 512 patients aged 0-14 years were diagnosed with T1D in Sardinia. The overall IR was 73.9 per 100,000 person-years (95 % CI 67.6-80.0). Since 1989, the SIR has increased by 2.3 % per year (CI 1.7-2.8, p < 0.0001). The frequency of ketoacidosis at onset was 26.4 %, with no significant differences among the four years.

Conclusions: The incidence of T1D in Sardinia, unlike in other countries such as Finland, has almost doubled in the last 20 years, and currently, it appears to be the highest in the world.

Keywords: Children; Incidence; Ketoacidosis; Type 1 diabetes.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The authors declare that they have no potential conflicts of interest related to this article. In the last 36 months, the authors reported the following conflicts of interest not specific to this work. C.R. received a speaker honorarium from Eli-Lilly and Sanofi and received support for attending meetings and travel from Medtronic, Theras, MOVI, and Roche. M.RC. received support for attending meetings and travel from Medtronic, Theras, and Roche. G.P. received support for attending meetings and travel from Medtronic, Theras, MOVI, and Roche. A.O. received support for attending meetings and travel from Medtronic, MOVI, and Theras. M.M.O., G.L.C., and A.C. received support for attending meetings and travel from Medtronic and MOVI. R.M. and M.P.S. received support for attending meetings and travel from Medtronic. M.R.A., G.M., A.P., G.P., V.C., P.B., L.C., and O.A. have no conflicts of interest to declare.

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