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Review
. 2024 Oct;598(20):2470-2481.
doi: 10.1002/1873-3468.14959. Epub 2024 Jun 17.

Diet predisposes to pancreatic cancer through cellular nutrient sensing pathways

Roberta Noè  1   2 , Alessandro Carrer  1   2
Affiliations
Free article
Review

Diet predisposes to pancreatic cancer through cellular nutrient sensing pathways

Roberta Noè et al. FEBS Lett. 2024 Oct.
Free article

Abstract

Pancreatic cancer is a lethal disease with limited effective treatments. A deeper understanding of its molecular mechanisms is crucial to reduce incidence and mortality. Epidemiological evidence suggests a link between diet and disease risk, though dietary recommendations for at-risk individuals remain debated. Here, we propose that cell-intrinsic nutrient sensing pathways respond to specific diet-derived cues to facilitate oncogenic transformation of pancreatic epithelial cells. This review explores how diet influences pancreatic cancer predisposition through nutrient sensing and downstream consequences for (pre-)cancer cell biology. We also examine experimental evidence connecting specific food intake to pancreatic cancer progression, highlighting nutrient sensing as a promising target for therapeutic development to mitigate disease risk.

Keywords: carbohydrates; diet; lipids; nutrient sensing; pancreatic cancer.

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