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. 2024 Oct;48(10):1162-1167.
doi: 10.1111/aor.14803. Epub 2024 Jun 18.

Peri-operative fever and LVAD: SIRS or impaired right ventricular strain?

Stefanie Marek-Iannucci  1 , Riley Wildemann  2 , Yevgeniy Brailovsky  1 , Samuel Dyer  3 , Maria T Gamero  1 , Rene J Alvarez  1 , Eduardo Rame  1 , Howard T Massey  4 , Vakhtang Tchantchaleishvili  4 , Brandi Thoma  2 , Indranee N Rajapreyar  1
Affiliations

Peri-operative fever and LVAD: SIRS or impaired right ventricular strain?

Stefanie Marek-Iannucci et al. Artif Organs. 2024 Oct.

Abstract

Background: An inflammatory milieu after left ventricular assist device (LVAD) implantation is associated with multi-organ dysfunction and pre-operative heightened inflammatory state is associated with right ventricular failure after LVAD implantation.

Methods: We performed a retrospective analysis of 30 LVAD patients in our institution within the last 2 years for the development of fever and compared them to 30 non-LVAD open-heart surgery patients.

Results: Our results suggest that patients undergoing LVAD implantation are more likely to develop fever in the immediate post-operative period compared to other open-heart surgeries. This is independent of pharmacological treatment, age, or ethnical background. Females and obese patients were more likely to develop fever.

Conclusion: Patients with right ventricular dysfunction, as demonstrated by elevated central venous pressure (CVP), had the strongest correlation with fever development. These results pose the question if there is a systemic inflammatory response-like phenomenon driven by increased right ventricular dysfunction.

Keywords: LVAD; fever; right ventricular failure.

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References

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