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. 2024 Jul 1;31(7):647-649.
doi: 10.1097/GME.0000000000002382. Epub 2024 Jun 17.

Menopause and brain fog: how to counsel and treat midlife women

Pauline M Maki  1 , Nicole G Jaff  2
Affiliations

Menopause and brain fog: how to counsel and treat midlife women

Pauline M Maki et al. Menopause. .

Abstract

Brain fog, referring to menopause-related subjective cognitive difficulties, is common in midlife women. Longitudinal studies find small but reliable declines in objective memory performance as women transition into perimenopause, and these are not explained by advancing age alone. When memory declines occur, performance levels remain within normal limits for all but a very small number of women. Women's experience of brain fog extends beyond memory complaints, reflecting the negative effect on a broad range of cognitive abilities. Clinicians can counsel women about how menopause symptoms, estrogen, hormone therapy, and modifiable risk factors (eg, hypertension, sedentary lifestyle) can influence cognitive health.

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References

    1. Maki PM, Jaff NG. Brain fog in menopause: a health-care professional’s guide for decision-making and counseling on cognition. Climacteric 2022;25:570–578. doi: 10.1080/13697137.2022.2122792 - DOI
    1. Epperson CN, Shanmugan S, Kim DR, et al. New onset executive function difficulties at menopause: a possible role for lisdexamfetamine. Psychopharmacology (Berl) 2015;232:3091–3100. doi: 10.1007/s00213-015-3953-7 - DOI
    1. Maki PM, Weber MT. A research primer for studies of cognitive changes across the menopause transition. Climacteric 2021;24:382–388. doi: 10.1080/13697137.2021.1905625 - DOI
    1. Drogos LL, Rubin LH, Geller S, et al. Objective cognitive performance is related to subjective memory complaints in midlife women with moderate to severe vasomotor symptoms. Menopause 2013;20:1236–1242. doi: 10.1097/GME.0b013e318291f5a6 - DOI
    1. Schaafsma M, Homewood J, Taylor A. Subjective cognitive complaints at menopause associated with declines in performance of verbal memory and attentional processes. Climacteric 2010;13:84–98. doi: 10.3109/13697130903009187 - DOI