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. 2024 Jul 12:7:e60686.
doi: 10.2196/60686.

Assessing the Relationship Between Vitiligo and Major Depressive Disorder Severity: Cross-Sectional Study

Amr Molla  1 , Raed Jannadi  2 , Hamza Alayoubi  3 , Haya Altouri  3 , Maryam Balkhair  3 , Dareen Hafez  4
Affiliations

Assessing the Relationship Between Vitiligo and Major Depressive Disorder Severity: Cross-Sectional Study

Amr Molla et al. JMIR Dermatol. .

Abstract

Background: Vitiligo, a common dermatological disorder in Saudi Arabia, is associated with significant psychological impacts. This study explores the relationship between vitiligo and the severity of major depressive disorder (MDD), highlighting the broader implications on mental health among affected individuals.

Objective: We aim to assess the prevalence and predictors of depression among adult patients with vitiligo, and to examine the relationship between MDD severity and vitiligo.

Methods: Using a cross-sectional design, the research used the vitiligo area severity index and the Patient Health Questionnaire-9 to measure the extent of vitiligo and depression severity, respectively. This study involved 340 diagnosed patients with vitiligo from various health care settings. Logistic and ordinal regression analysis were applied to evaluate the impact of sociodemographic variables and vitiligo types on MDD severity.

Results: The prevalence of MDD was 58.8% (200/340) of participants. Depression severity varied notably: 18.2% (62/340) of patients experienced mild depression, 17.9% (61/340) moderate, 11.8% (40/340) moderately severe, and 10.9% (37/340) severe depression. Female patients had higher odds of severe depression than male patients (adjusted odds ratio [aOR] 3.14, 95% CI 1.93-5.1; P<.001). Age was inversely related to depression severity, with patients aged older than 60 years showing significantly lower odds (aOR 0.1, 95% CI 0.03-0.39; P<.001). Lower income was associated with higher depression severity (aOR 10.2, 95% CI 3.25-31.8; P<.001). Vitiligo types also influenced depression severity; vulgaris (aOR 5.3, 95% CI 2.6-10.9; P<.001) and acrofacial vitiligo (aOR 2.8, 95% CI 1.5-5.1; P<.001) were significantly associated with higher depression levels compared to focal vitiligo.

Conclusions: The findings suggest that vitiligo contributes to an increased risk of severe depression, highlighting the need for integrated dermatological and psychological treatment approaches to address both the physical and mental health aspects of the disease.

Keywords: PHQ-9; Patient Health Questionnaire-9; Saudi Arabia; cross-sectional study; depression severity; major depressive disorder (MDD); vitiligo.

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Conflict of interest statement

Conflicts of Interest: None declared.

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References

    1. Wolff K, Goldsmith LA, Katz S, Gilchrest BA, Paller AS, Leffell DJ. Fitzpatrick's dermatology in general medicine: mcgraw-hill New York; 2008. New York: McGraw Hill Professional; 2008. p. 3154.
    1. Simons RE, Zevy DL, Jafferany M. Psychodermatology of vitiligo: psychological impact and consequences. Dermatol Ther. 2020;33(3):e13418. doi: 10.1111/dth.13418. - DOI - PubMed
    1. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS, National Comorbidity Survey Replication The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R) JAMA. 2003;289(23):3095–3105. doi: 10.1001/jama.289.23.3095.289/23/3095 - DOI - PubMed
    1. Vallerand IA, Lewinson RT, Parsons LM, Hardin J, Haber RM, Lowerison MW, Barnabe C, Patten SB. Vitiligo and major depressive disorder: a bidirectional population-based cohort study. J Am Acad Dermatol. 2019;80(5):1371–1379. doi: 10.1016/j.jaad.2018.11.047.S0190-9622(18)32982-7 - DOI - PubMed
    1. Lai YC, Yew YW, Kennedy C, Schwartz RA. Vitiligo and depression: a systematic review and meta-analysis of observational studies. Br J Dermatol. 2017;177(3):708–718. doi: 10.1111/bjd.15199. - DOI - PubMed

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