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Review
. 2024 Dec;30(12):1113-1125.
doi: 10.1016/j.molmed.2024.05.012. Epub 2024 Jun 17.

Senescence and tissue fibrosis: opportunities for therapeutic targeting

Affiliations
Review

Senescence and tissue fibrosis: opportunities for therapeutic targeting

Steven O'Reilly et al. Trends Mol Med. 2024 Dec.

Abstract

Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in normal tissue turnover and is associated with a variety of age-related diseases, including organ-specific fibrosis and systemic sclerosis (SSc). This review discusses the recent evidence of the role of senescence in tissue fibrosis, with an emphasis on SSc, a systemic autoimmune rheumatic disease. We discuss the physiological role of these cells, their role in fibrosis, and that targeting these cells specifically could be a new therapeutic avenue in fibrotic disease. We argue that targeting senescent cells, with senolytics or senomorphs, is a viable therapeutic target in fibrotic diseases which remain largely intractable.

Keywords: SASP; fibrosis; myofibroblasts; senescence; systemic sclerosis.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

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