Senescence and tissue fibrosis: opportunities for therapeutic targeting
- PMID: 38890028
- DOI: 10.1016/j.molmed.2024.05.012
Senescence and tissue fibrosis: opportunities for therapeutic targeting
Abstract
Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in normal tissue turnover and is associated with a variety of age-related diseases, including organ-specific fibrosis and systemic sclerosis (SSc). This review discusses the recent evidence of the role of senescence in tissue fibrosis, with an emphasis on SSc, a systemic autoimmune rheumatic disease. We discuss the physiological role of these cells, their role in fibrosis, and that targeting these cells specifically could be a new therapeutic avenue in fibrotic disease. We argue that targeting senescent cells, with senolytics or senomorphs, is a viable therapeutic target in fibrotic diseases which remain largely intractable.
Keywords: SASP; fibrosis; myofibroblasts; senescence; systemic sclerosis.
Copyright © 2024 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no conflicts of interest.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical