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. 2024 Aug;56(6):557-563.
doi: 10.1002/lsm.23812. Epub 2024 Jun 18.

Optical Effects of Focused Fractional Nanosecond 1064-nm Nd:YAG Laser: Techniques of Application on Human Skin

Connie Liu  1   2 , Hsin-Yi Huang  3 , Yu-Yang Chang  1 , Chi-Kuang Sun  4   5 , Shih-Hsuan Chia  1   6 , Yi-Hua Liao  7
Affiliations

Optical Effects of Focused Fractional Nanosecond 1064-nm Nd:YAG Laser: Techniques of Application on Human Skin

Connie Liu et al. Lasers Surg Med. 2024 Aug.

Abstract

Background and objectives: Considering the pulse widths of picosecond and nanosecond lasers used in cutaneous laser surgery differ by approximately one order of magnitude, can nanosecond lasers produce the optical effect in human skin similar to laser-induced optical breakdown (LIOB) caused by picosecond lasers?

Methods: Cutaneous changes induced by a focused fractional nanosecond 1064-nm Nd:YAG laser were evaluated by VISIA-CR imaging, histological examination, and harmonic generation microscopy (HGM).

Results: A focused fractional nanosecond 1064-nm Nd:YAG laser can generate epidermal vacuoles or dermal cavities similar to the phenomenon of LIOB produced by picosecond lasers. The location and extent of photodisruption can be controlled by the laser fluence and focus depth. Moreover, laser-induced shock wave propagation and thermal degeneration of papillary collagen can be observed by HGM imaging.

Conclusion: Focused fractional nanosecond lasers can produce an optical effect on human skin similar to LIOB caused by picosecond lasers. With techniques of application, the treatment can induce epidermal and dermal repair mechanisms in a tunable fashion to improve skin texture, wrinkles, scars, and dyspigmentation, without disrupting the epidermal surface.

Keywords: facial rejuvenation; fractional Nd:YAG laser; harmonic generation microscopy; optical breakdown.

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