Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May 31;16(11):1555.
doi: 10.3390/polym16111555.

Improving Hemocompatibility of Polysulfone Membrane by UV-Assisted Grafting of Sulfonated Chitosan

Sheng Yan  1 , Yunren Qiu  1
Affiliations

Improving Hemocompatibility of Polysulfone Membrane by UV-Assisted Grafting of Sulfonated Chitosan

Sheng Yan et al. Polymers (Basel). .

Abstract

The most prevalent type of hemodialysis membrane is polysulfone (PSf). However, due to inadequate biocompatibility, it significantly compromises the safety of dialysis for patients. In this study, we modify the surface of the PSf membrane with 2,4-dihydroxybenzophenone (DBPh) groups to serve as anchoring sites during UV irradiation. Subsequently, a tailored sulfonated dihydroxy propyl chitosan (SDHPCS) is grafted onto the modified PSf membrane to compensate for the deficiencies in hydrophilic additives. The modified PSf membrane exhibits outstanding hydrophilicity and stability, as demonstrated by its characterization and evaluation. This paper focuses on investigating the interaction between platelet membrane formation, protein adsorption, and anticoagulant activity. The results show that the modified PSf membrane exhibits remarkable enhancement in surface hydrophilicity, leading to a significant reduction in protein and platelet adsorption as well as adhesion.

Keywords: chitosan; graft; hemocompatibility; hydrophilicity; polysulfone.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Scheme 1
Scheme 1
The synthesis procedure of graft 2,4-dihydroxybenzophenone and sulfonated dihydroxy propyl chitosan onto the PSf membrane surface.
Figure 1
Figure 1
The FTIR spectra of CS, DHPCS, and SDHPCS.
Figure 2
Figure 2
Static water contact angles for different membranes (a); the BSA adsorption on the surfaces of PSf, PSf-OH, and PSf-SDHPCS membranes (b). Data are expressed as the mean ± SD of six independent measurements.
Figure 3
Figure 3
ATR-FTIR spectra (a) and XPS C1s and Sp2 high resolution spectra (b–h) of the PSf, PSf-OH, and PSf-SDHPCS membranes.
Figure 3
Figure 3
ATR-FTIR spectra (a) and XPS C1s and Sp2 high resolution spectra (b–h) of the PSf, PSf-OH, and PSf-SDHPCS membranes.
Figure 4
Figure 4
The SEM images (a–c) PSf, PSf-OH, and PSf-SDHPCS membranes surface; the SEM image of cross section (d–f) of PSf, PSf-OH, and PSf-SDHPCS membranes.
Figure 5
Figure 5
The SEM images (a–f) of PSf, PSf-OH, and PSf-SDHPCS membranes with adsorbed platelets. Magnification: 1000× (a–c); magnification: 5000× (d–f).
Figure 6
Figure 6
The hemolysis ratios (a) and plasma recalcification times (b) of PSf, PSf-OH, and PSf-SDHPCS membranes.
Figure 7
Figure 7
APTT, PT, and TT of PSf, PSf-OH, and PSf-SDHPCS membranes.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Lufrano F., Squadrito G., Patti A., Passalacqua E. Sulfonated Polysulfone as Promising Membranes for Polymer Electrolyte Fuel Cells. J. Appl. Polym. Sci. 2015;77:1250–1256. doi: 10.1002/1097-4628(20000808)77:6<1250::AID-APP9>3.0.CO;2-R. - DOI
    1. Ishihara K., Fukumoto K., Iwasaki Y., Nakabayashi N. Modification of Polysulfone with Phospholipid Polymer for Improvement of the Blood Compatibility. Part 1. Surface Characterization. Biomaterials. 1999;20:1545–1551. doi: 10.1016/S0142-9612(99)00052-6. - DOI - PubMed
    1. Barton A.J., Sagers R.D., Pitt W.G. Bacterial Adhesion to Orthopedic Implant Polymers. J. Biomed. Mater. Res. Part B Appl. Biomater. 2015;30:403–410. doi: 10.1002/(SICI)1097-4636(199603)30:3<403::AID-JBM15>3.0.CO;2-K. - DOI - PubMed
    1. Saedi S., Madaeni S.S., Arabi Shamsabadi A., Mottaghi F. The Effect of Surfactants on the Structure and Performance of PES Membrane for Separation of Carbon Dioxide from Methane. Sep. Purif. Technol. 2012;99:104–119. doi: 10.1016/j.seppur.2012.08.028. - DOI
    1. Tran C., Hallahan N., Kosobrodova E., Tong J., Thorn P., Bilek M. Plasma Surface Engineering to Biofunctionalise Polymers for β-Cell Adhesion. Coatings. 2021;11:1085. doi: 10.3390/coatings11091085. - DOI

LinkOut - more resources