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Review
. 2024 May 24;25(11):5723.
doi: 10.3390/ijms25115723.

Probiotics in Wound Healing

Valentina Alexandra Bădăluță  1   2 , Carmen Curuțiu  1   2 , Lia Mara Dițu  1   2 , Alina Maria Holban  1   2 , Veronica Lazăr  1   2
Affiliations
Review

Probiotics in Wound Healing

Valentina Alexandra Bădăluță et al. Int J Mol Sci. .

Abstract

Wound infections caused by opportunistic bacteria promote persistent infection and represent the main cause of delayed healing. Probiotics are acknowledged for their beneficial effects on the human body and could be utilized in the management of various diseases. They also possess the capacity to accelerate wound healing, due to their remarkable anti-pathogenic, antibiofilm, and immunomodulatory effects. Oral and topical probiotic formulations have shown promising openings in the field of dermatology, and there are various in vitro and in vivo models focusing on their healing mechanisms. Wound dressings embedded with prebiotics and probiotics are now prime candidates for designing wound healing therapeutic approaches to combat infections and to promote the healing process. The aim of this review is to conduct an extensive scientific literature review regarding the efficacy of oral and topical probiotics in wound management, as well as the potential of wound dressing embedding pre- and probiotics in stimulating the wound healing process.

Keywords: infection control; probiotic formulations; wound dressings; wound healing.

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Conflict of interest statement

The authors declare no conflicts of interests.

Figures

Figure 1
Figure 1
Probiotic mechanisms associated with improved wound healing (created with BioRender.com, accessed on 31 March 2024).
Figure 2
Figure 2
Properties and main advantages of probiotic- and prebiotic-containing dressings (created with BioRender.com, accessed on 10 April 2024).
See this image and copyright information in PMC

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