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Review
. 2024 May 29;25(11):5956.
doi: 10.3390/ijms25115956.

GDF15, an Emerging Player in Renal Physiology and Pathophysiology

Samia Lasaad  1 , Gilles Crambert  2   3
Affiliations
Review

GDF15, an Emerging Player in Renal Physiology and Pathophysiology

Samia Lasaad et al. Int J Mol Sci. .

Abstract

These last years, the growth factor GDF15 has emerged as a key element in many different biological processes. It has been established as being produced in response to many pathological states and is now referred to as a stress-related hormone. Regarding kidney functions, GDF15 has been involved in different pathologies such as chronic kidney disease, diabetic nephropathy, renal cancer, and so on. Interestingly, recent studies also revealed a role of GDF15 in the renal homeostatic mechanisms allowing to maintain constant, as far as possible, the plasma parameters such as pH and K+ values. In this review, we recapitulate the role of GDF15 in physiological and pathological context by focusing our interest on its renal effect.

Keywords: GDF15; K+ balance; acid/base homeostasis; cell proliferation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of gene (A) and protein (B) structures of GDF15.
Figure 2
Figure 2
Expression of GDF15 along the nephrons. (A) Renal segments isolated under binocular after treatment of kidneys with Liberase (Sigma-Aldrich, St Quentin Fallavier, France) as described in [38] were used for RNA extraction and qPCR analysis as described in [38] for measuring expression of GDF15 (B). This expression is normalized with that of a housekeeping gene, cyclophilin (PPIA).
Figure 3
Figure 3
GDF15 in response to ischemia/reperfusion. (A,B) Analysis by scRNAseq of GDF15 expression in kidney cells after ischemia/reperfusion from http://www.susztaklab.com/Mouse_IRI_scRNA/Genemap.php accessed on 1 April 2024.
Figure 4
Figure 4
(A) Schematic representation of GDF15 production by principal cells and its proliferative effect on type A intercalated cells in the context of acid load. (B) Schematic representation of GDF15 effect on type A intercalated cells in the context of K+ restriction.
See this image and copyright information in PMC

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